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The Swiss Cheese Mutant Causes Glial Hyperwrapping and Brain Degeneration in Drosophila

Kretzschmar, Doris and Hasan, Gaiti and Sharma, Sugandha and Heisenberg, Martin and Benzer, Seymour (1997) The Swiss Cheese Mutant Causes Glial Hyperwrapping and Brain Degeneration in Drosophila. Journal of Neuroscience, 17 (19). pp. 7425-7432. ISSN 0270-6474. PMCID PMC6573436. https://resolver.caltech.edu/CaltechAUTHORS:20190228-115827867

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Abstract

Swiss cheese (sws) mutant flies develop normally during larval life but show age-dependent neurodegeneration in the pupa and adult and have reduced life span. In late pupae, glial processes form abnormal, multilayered wrappings around neurons and axons. Degeneration first becomes evident in young flies as apoptosis in single scattered cells in the CNS, but later it becomes severe and widespread. In the adult, the number of glial wrappings increases with age. The sws gene is expressed in neurons in the brain cortex. The conceptual 1425 amino acid protein shows two domains with homology to the regulatory subunits of protein kinase A and to conceptual proteins of yet unknown function in yeast, worm, and human. Sequencing of two sws alleles shows amino acid substitutions in these two conserved domains. It is suggested that the novel SWS protein plays a role in a signaling mechanism between neurons and glia that regulates glial wrapping during development of the adult brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.17-19-07425.1997DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573436PubMed CentralArticle
Additional Information:© 1997 Society for Neuroscience. Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received March 3, 1997; revised July 8, 1997; accepted July 11, 1997. This work was supported by fellowships to D.K. from the French Foundation for Alzheimer Research and the Deutsche Forschungsgemeinschaft (Kr 1507/1-1), and Research Grants to S.B. from the National Institute of Aging (AG12289), the National Eye Institute (EY09287), the National Science Foundation (MCB-9408718), the McKnight Foundation, and the James G. Boswell Foundation. We thank Rosalind Young and Lynette Dowling for excellent technical assistance and the members of Prof. Benzer’s research group for valuable discussions. Special thanks are due to the sequencing and oligosynthesizing facilities at Caltech.
Funders:
Funding AgencyGrant Number
John Douglas French Alzheimer’s FoundationUNSPECIFIED
Deutsche Forschungsgemeinschaft (DFG)Kr 1507/1-1
NIHAG12289
NIHEY09287
NSFMCB-9408718
McKnight FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:Drosophila; adult central nervous system; apoptosis; glia–neuron interaction; neurodegeneration; reduced life span
Issue or Number:19
PubMed Central ID:PMC6573436
Record Number:CaltechAUTHORS:20190228-115827867
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190228-115827867
Official Citation:The Swiss Cheese Mutant Causes Glial Hyperwrapping and Brain Degeneration in Drosophila Doris Kretzschmar, Gaiti Hasan, Sugandha Sharma, Martin Heisenberg, Seymour Benzer Journal of Neuroscience 1 October 1997, 17 (19) 7425-7432; DOI: 10.1523/JNEUROSCI.17-19-07425.1997
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93349
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:28 Feb 2019 21:52
Last Modified:28 Oct 2019 17:01

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