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Glia in the chiasms and medulla of the Drosophila melanogaster optic lobes

Tix, Simone and Eule, Eckhart and Fischbach, Karl-Friedrich and Benzer, Seymour (1997) Glia in the chiasms and medulla of the Drosophila melanogaster optic lobes. Cell and Tissue Research, 289 (3). pp. 397-409. ISSN 0302-766X. https://resolver.caltech.edu/CaltechAUTHORS:20190228-115827974

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Abstract

Different classes of glia cells in the optic lobes of Drosophila melanogaster were defined by the enhancer trap technique, using expression of the lacZ reporter gene. At both the outer and inner optic chiasms, there are stacks of glia, arrayed from dorsal to ventral, interpersed between the crossings of axonal fiber bundles. The giant glial cells of both the outer and inner chiasms are similar with respect to their nuclear shapes and positions, indicating similar functions of these cell types. Another class of glia is found in the medulla neuropil. Their cell bodies anchor in the most distal region of the neuropil, and their processes extend into the deeper neuropil layers. Birth dating using BrdU shows that both groups of chiasm glia are born early in larval life; they may participate in the development of the optic lobe. The medulla glia are born later and may be involved primarily in adult functions. In the wild type, and in mutants with structurally altered optic lobes, the numbers of tract-associated glial cells in the outer and inner optic chiasms seem to vary with the number of visual columns, whereas the complement of medulla neuropil glia correlates with the volume of the optic lobe.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1007/s004410050886DOIArticle
https://rdcu.be/boUdhPublisherFree ReadCube access
Additional Information:© Springer-Verlag Berlin Heidelberg 1997. Received: 12 November 1996 / Accepted: 24 February 1997 We thank Christian Klämbt for supplying enhancer trap lines, expert practical advice and helpful discussions, and Thilo Schneider and Simone Peterreins for their participation in screening lines. Rosalind Young and Karen Chang provided superb technical assistance. We are also grateful to the members of the Benzer lab for critically reading the manuscript. This work was supported by a postdoctoral fellowship from the Deutsche Forschungsgemeinschaft to S.T. (Ti 236/1-1) and a grant to K.F.F. (SFB 505), the Fond der Chemischen Industrie and grants to S.B. from the National Science Foundation (MCB 9408718), the National Institutes of Health (EY 09278 and AG12289), the McKnight Foundation, and the James G. Boswell Foundation.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)Ti 236/1-1
Deutsche Forschungsgemeinschaft (DFG)SFB 50
Fond der Chemischen IndustrieUNSPECIFIED
NSFMCB-9408718
NIHEY09278
NIHAG12289
McKnight FoundationUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Subject Keywords:Glia – Chiasm formation – BrdU-birth dating – Enhancer trap technique – Structural brain mutants – Drosophila melanogaster (Insecta)
Issue or Number:3
Record Number:CaltechAUTHORS:20190228-115827974
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190228-115827974
Official Citation:Tix, S., Eule, E., Fischbach, KF. et al. Cell Tissue Res (1997) 289: 397. https://doi.org/10.1007/s004410050886
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93350
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:28 Feb 2019 20:53
Last Modified:03 Oct 2019 20:53

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