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Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

Choi, Kwang-Wook and Benzer, Seymour (1994) Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene. Cell, 78 (1). pp. 125-136. ISSN 0092-8674.

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The Drosophila eye consists of a reiterative hexagonal array of photoreceptor cell clusters, the ommatidia. During normal morphogenesis, the clusters in the dorsal or ventral halves of the disc rotate 90° in opposite directions, forming mirror images across a dorsoventral equator. In the mutant nemo (nmo), there is an initial turning of approximately 45°, but further rotation is blocked. Genetic mosaic analysis indicates that the nmo gene acts upon each cluster as a whole; normal nmo function in one or more photoreceptor cells appears to be sufficient to induce full rotation. The nmo gene sequence encodes a serine/threonine protein kinase homolog, suggesting that the kinase is required to initiate the second step of rotation. In another mutant, roulette, excessive rotation through varying angles occurs in many ommatidia. This defect is suppressed by nmo, indicating that nmo acts upstream in a rotation-regulating pathway.

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Additional Information:© 1994 Cell Press. Received 20 October 1993, Revised 26 May 1994. Address correspondence lo S. B. We thank Rosalind Young and Lynette Dowling for expert technical assistance, and our colleagues for suggestions on the manuscript. We thank William Leiserson for the r/t mutant, Gary Hime and Robert Saint for pbl deficiency stocks, John Tamkun for the cosmid library, and Kalpana White for anti-elav antibody. We are indebted to an anonymous reviewer for the suggestion to use the P[w^+]33 strain for mosaic analysis and to Todd Laverty of Gerald Rubin’s laboratory for furnishing the strain. This research was supported by a postdoctoral fellowship (to K.-W. C.) from the Drown Foundation and grants (to S. B.) from the National Science Foundation (BCS-8908154), the National Eye Institute of the National Institutes of Health (EY09278), and the James G. Boswell Foundation.
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Official Citation:Kwang-Wook Choi, Seymour Benzer, Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene, Cell, Volume 78, Issue 1, 1994, Pages 125-136, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93375
Deposited By: George Porter
Deposited On:01 Mar 2019 00:17
Last Modified:03 Oct 2019 20:53

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