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High-resolution ultrasound-aided biophotonic imaging

Wang, Lihong V. and Wang, Xueding and Ku, Geng and Xie, Xueyi and Stoica, George (2004) High-resolution ultrasound-aided biophotonic imaging. In: 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 5307-5310. ISBN 0780384393.

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Optical contrast is sensitive to functional parameters, including the oxygen saturation and total concentration of hemoglobin, in biological tissues. However, due to the overwhelming scattering encountered by light in tissues, traditional optical modalities cannot provide satisfactory spatial resolution beyond the ballistic (a few hundred microns) and quasiballistic (1-2 mm) regimes. Photoacoustic tomography is based on the high optical contrast yet utilizing the high ultrasonic resolution. Our work in this emerging area of research will be summarized in this invited talk. In this technology, a diffraction-based inverse-source problem is solved in the image reconstruction, for which we developed the rigorous reconstruction theory. We implemented a prototype and accomplished noninvasive transdermal and transcranial functional imaging of small-animal brains in vivo. Change in the cerebral blood oxygenation of a rat, as a result of the alternation from hyperoxia to hypoxia, was imaged successfully.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Stoica, George0000-0001-8071-4828
Additional Information:© 2004 IEEE. This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17–00-1–0455, the National Institutes of Health Grants No. R01 EB000712 and No. R01 NS46214, and Texas Higher Education Coordinating Board Grant No. ARP 000512–0063-2001.
Funding AgencyGrant Number
Army Medical Research and Materiel CommandDAMD17-00-1-0455
NIHR01 EB000712
NIHR01 NS46214
Texas Higher Education Coordinating BoardARP 000512-0063-2001
Subject Keywords:Photoacoustic tomography, optical contrast, ultrasonic resolution, inverse-source reconstruction, oxygen saturation of hemoglobin
Record Number:CaltechAUTHORS:20190304-140403933
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Official Citation:L. V. Wang, Xueding Wang, Geng Ku, Xueyi Xie and G. Stoica, "High-resolution ultrasound-aided biophotonic imaging," The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, San Francisco, CA, 2004, pp. 5307-5310. doi: 10.1109/IEMBS.2004.1404482
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93447
Deposited By: George Porter
Deposited On:04 Mar 2019 22:27
Last Modified:16 Nov 2021 16:57

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