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High-Resolution Photoacoustic Tomography In Vivo

Wang, Lihong V. and Li, Meng-Lin and Zhang, Hao F. and Maslov, Konstantin and Stoica, George (2006) High-Resolution Photoacoustic Tomography In Vivo. In: 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006. IEEE , Piscataway, NJ, pp. 1204-1207. ISBN 078039576X.

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An in vivo backward-mode photoacoustic microscope was recently developed that employs a high frequency, broadband, large numerical aperture (NA) focused ultrasonic transducer to provide high resolution and high sensitivity. However, out of the focus region, the limited depth of focus deteriorated the image quality significantly. Based on a virtual-detector concept, we devised and implemented a synthetic aperture focusing technique in combination with coherence weighting to overcome this drawback. This technique improved the -6-dB lateral resolution from 50-265 microns to 46-55 microns and increased the SNR by up to 23 dB. In vivo experiments showed that the technique provided a clearer representation of the vascular distribution in the dorsal dermis of a rat.

Item Type:Book Section
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URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Maslov, Konstantin0000-0003-3408-8840
Stoica, George0000-0001-8071-4828
Additional Information:© 2006 IEEE.
Record Number:CaltechAUTHORS:20190304-143522577
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Official Citation:L. V. Wang, Meng-Lin Li, H. F. Zhang, K. Maslov and G. Stoica, "High-resolution photoacoustic tomography in vivo," 3rd IEEE International Symposium on Biomedical Imaging: Nano to Macro, 2006., Arlington, VA, 2006, pp. 1204-1207. doi: 10.1109/ISBI.2006.1625140
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93458
Deposited By: George Porter
Deposited On:05 Mar 2019 19:05
Last Modified:16 Nov 2021 16:57

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