A Caltech Library Service

Combined Photoacoustic and Molecular Fluorescence Imaging In Vivo

Wang, Lihong V. and Xie, Xueyi and Oh, Jung-Taek and Li, Meng-Lin and Ku, Geng and Ke, Shi and Similache, Sergiu and Li, Chun and Stoica, George (2005) Combined Photoacoustic and Molecular Fluorescence Imaging In Vivo. In: 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE , Piscataway, NJ, pp. 190-192. ISBN 0780387414.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural images of tumor angiogenesis, and fluorescence imaging offers high sensitivity to molecular probes for tumor detection. Coregistration of the PAT and fluorescence images was performed on nude mice with M21 human melanoma cell lines with alpha_vbeta_3 integrin expression. An integrin alpha_vbeta_3-targeted peptide-ICG conjugated NIR fluorescent contrast agent was used as the molecular probe for tumor detection. PAT was employed to noninvasively image the brain structure and the angiogenesis associated with tumors in mice. The coregistration between the PAT and fluorescence images was used to visualize tumor location, angiogenesis, and brain structure simultaneously.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Stoica, George0000-0001-8071-4828
Additional Information:© 2005 IEEE. This study is sponsored in part by National Institutes of Health grants R01 EB000712 and R01 NS46214.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Record Number:CaltechAUTHORS:20190304-143522670
Persistent URL:
Official Citation:L. V. Wang et al., "Combined Photoacoustic and Molecular Fluorescence Imaging In Vivo," 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference, Shanghai, 2005, pp. 190-192. doi: 10.1109/IEMBS.2005.1616374
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93459
Deposited By: George Porter
Deposited On:05 Mar 2019 19:00
Last Modified:16 Nov 2021 16:57

Repository Staff Only: item control page