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High-resolution spectroscopic photoacoustic tomography for non-invasive functional imaging of small-animal brains in vivo

Wang, Lihong V. and Wang, Xueding and Ku, Geng and Xie, Xueyi and Stoica, George (2004) High-resolution spectroscopic photoacoustic tomography for non-invasive functional imaging of small-animal brains in vivo. In: Second Asian and Pacific Rim Symposium on Biophotonics, 2004. IEEE , Piscataway, NJ, pp. 246-247. ISBN 0780386760. https://resolver.caltech.edu/CaltechAUTHORS:20190304-143522758

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Abstract

Based on the multiwavelength laser-based photoacoustic tomography, noninvasive imaging of cerebral blood oxygenation and blood volume in small-animal brains in vivo was realized. The high sensitivity of this technique is based on the spectroscopic differences between oxy- and deoxy-hemoglobins whereas its spatial resolution is diffraction-limited by the photoacoustic signals. The point-by-point distributions of hemoglobin oxygen saturation and total concentration of hemoglobin in the cerebral cortical venous vessels, altered by systemic physiological modulations including hyperoxia and hypoxia, were visualized successfully through the intact skin and skull. This technique can potentially accelerate the progress in neuroscience and provide important new insights into cerebrovascular physiology and brain function.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/apbp.2004.1412374DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Stoica, George0000-0001-8071-4828
Additional Information:© 2004 IEEE.
DOI:10.1109/apbp.2004.1412374
Record Number:CaltechAUTHORS:20190304-143522758
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190304-143522758
Official Citation:L. V. Wang, X. Wang, G. Ku, X. Xie and G. Stoica, "High-resolution spectroscopic photoacoustic tomography for noninvasive functional imaging of small-animal brains in vivo," The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004., Taipei, Taiwan, 2004, pp. 246-247. doi: 10.1109/APBP.2004.1412374
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93460
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Mar 2019 18:20
Last Modified:16 Nov 2021 16:57

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