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High-resolution photoacoustic tomography

Wang, Lihong V. and Wang, Xueding and Ku, Geng and Xie, Xueyi and Stoica, George (2004) High-resolution photoacoustic tomography. In: 17th Annual Meeting of the IEEE Lasers and Electro-Optics Society, 2004. Vol.2. IEEE , Piscataway, NJ, pp. 767-768. ISBN 0780385578.

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Optical contrast is sensitive to physiological parameters, such as the oxygen saturation and total concentration of hemoglobin, in biological tissues. Photoacoustic tomography is based on the high optical contrast yet utilizing the high ultrasonic resolution. Our work in this emerging area of research will be summarized in this invited talk. In this technology, a diffraction-based inverse-source problem is solved in the image reconstruction, for which we developed the rigorous reconstruction theory. We implemented a prototype and accomplished non-invasive transdermal and transcranial functional imaging of small-animal brains in vivo. Changes in the cerebral blood oxygenation and blood volume of a rat, as a result of the alternation from hyperoxia to hypoxia, were imaged successfully.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Wang, Lihong V.0000-0001-9783-4383
Stoica, George0000-0001-8071-4828
Additional Information:© 2004 IEEE. This project was sponsored in part by the U.S. Army Medical Research and Materiel Command Grant No. DAMD17-00-1-0455 the National Institutes of Health Grants No. R01 EB000712 and No. R01 NS46214, and Texas Higher Education Coordinating Board Grant No. ARP 000512-0063-2001.
Funding AgencyGrant Number
Army Medical Research and Materiel CommandDAMD17-00-1-0455
NIHR01 EB000712
NIHR01 NS46214
Texas Higher Education Coordinating Board000512-0063-2001
Subject Keywords:Photoacoustic tomography; optical contrast; ultrasonic resolution; inverse-source reconstruction; oxygen saturation of hemoglobin
Record Number:CaltechAUTHORS:20190304-143523017
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Official Citation:L. V. Wang, Xueding Wang, Geng Ku, Xueyi Xie and G. Stoica, "High-resolution photoacoustic tomography," The 17th Annual Meeting of the IEEELasers and Electro-Optics Society, 2004. LEOS 2004., Rio Grande, Puerto Rico, 2004, pp. 767-768 Vol.2. doi: 10.1109/LEOS.2004.1363465
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93463
Deposited By: George Porter
Deposited On:05 Mar 2019 18:04
Last Modified:16 Nov 2021 16:57

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