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Photoacoustic Tomography: Beat Optical Diffusion and Diffraction

Wang, Lihong V. and Beare, Gene K. (2014) Photoacoustic Tomography: Beat Optical Diffusion and Diffraction. In: Biomedical Optics 2014, OSA Technical Digest. Optical Society of America , Washington, D.C., Art. No. BS4A.1. ISBN 9781557529978.

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We develop photoacoustic tomography technologies for in vivo functional, metabolic, molecular, and histologic imaging by physically combining non-ionizing electromagnetic and ultrasonic waves. Broad applications include early-cancer detection and brain imaging. Unlike ionizing x-ray radiation, non-ionizing electromagnetic waves—such as optical and radio waves—pose no health hazard and reveal new contrast mechanisms. Unfortunately, electromagnetic waves in the non-ionizing spectral region do not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution tomography based on non-ionizing electromagnetic waves alone—such as confocal microscopy, two-photon microscopy, and optical coherence tomography—is limited to superficial imaging within approximately one optical transport mean free path (~1 mm in the skin) of the surface of scattering tissue. Ultrasonic imaging, on the contrary, provides good image resolution but suffers strong speckle artifacts as well as poor contrast in early-stage tumors. Ultrasound-mediated imaging modalities that combine electromagnetic and ultrasonic waves can synergistically overcome the above limitations. The hybrid modalities provide relatively deep penetration at high ultrasonic resolution and yield speckle-free images with high electromagnetic contrast.

Item Type:Book Section
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2014 Optical Society of America.
Record Number:CaltechAUTHORS:20190304-152756984
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Official Citation:L. V. Wang and G. K. Beare, "Photoacoustic Tomography: Beat Optical Diffusion and Diffraction," in Biomedical Optics 2014, OSA Technical Digest (online) (Optical Society of America, 2014), paper BS4A.1.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93490
Deposited By: George Porter
Deposited On:05 Mar 2019 21:23
Last Modified:03 Oct 2019 20:54

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