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Feedback regulation of the heat shock response in E. coli

Kurata, H. and El-Samad, H. and Yi, T.-M. and Khammash, M. and Doyle, J. (2001) Feedback regulation of the heat shock response in E. coli. In: Proceedings of the 40th IEEE Conference on Decision and Control. IEEE , Piscataway, NJ, pp. 837-842. ISBN 0780370619. https://resolver.caltech.edu/CaltechAUTHORS:20190304-154305641

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Abstract

Survival of organisms in extreme conditions has necessitated the evolution of stress response networks that detect and respond to environmental changes. Among the extreme conditions that cells must face is the exposure to higher than normal temperatures. In this paper, we propose a detailed biochemical model that captures the dynamical nature of the heat-shock response in Escherichia coli. Using this model, we show that both feedback and feedforward control are utilized to achieve robustness, performance, and efficiency of the response to the heat stress. We discuss the evolutionary advantages that feedback confers to the system, as compared to other strategies that could have been implemented to get the same performance.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/cdc.2001.980210DOIArticle
ORCID:
AuthorORCID
Doyle, J.0000-0002-1828-2486
Additional Information:© 2001 IEEE. The authors would like to acknowledge support from the EPRI/DOD Complex Interactive Network Program, the Kitano ERATO project, the New Energy and Industrial Technology Development Organization (NEDO), and ISU SPRIGS Grant.
Funders:
Funding AgencyGrant Number
Department of DefenseUNSPECIFIED
Exploratory Research for Advanced Technology (ERATO)UNSPECIFIED
New Energy and Industrial Technology Development Organization (NEDO)UNSPECIFIED
Iowa State UniversityUNSPECIFIED
Electric Power Research Institute (EPRI)UNSPECIFIED
Record Number:CaltechAUTHORS:20190304-154305641
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190304-154305641
Official Citation:H. Kurata, H. El-Samad, T. -. Yi, M. Khammash and J. Doyle, "Feedback regulation of the heat shock response in E. coli," Proceedings of the 40th IEEE Conference on Decision and Control (Cat. No.01CH37228), Orlando, FL, USA, 2001, pp. 837-842 vol.1. doi: 10.1109/CDC.2001.980210
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93509
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Mar 2019 23:52
Last Modified:03 Oct 2019 20:55

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