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Photoacoustic tomography: Ultrasonically breaking through the optical diffusion and diffraction limits

Wang, Lihong V. and Beare, Gene K. (2013) Photoacoustic tomography: Ultrasonically breaking through the optical diffusion and diffraction limits. In: 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference. IEEE , Piscataway, NJ, Art. No. CL_1ECBO_1. ISBN 9781479905942. https://resolver.caltech.edu/CaltechAUTHORS:20190305-122048141

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Abstract

We develop photoacoustic imaging technologies for in vivo early-cancer detection and functional, metabolic, molecular, and histologic imaging by physically combining non-ionizing electromagnetic and ultrasonic waves. Unlike ionizing x-ray radiation, non-ionizing electromagnetic waves - such as optical and radio waves - pose no health hazard and reveal new contrast mechanisms. Unfortunately, electromagnetic waves in the non-ionizing spectral region do not penetrate biological tissue in straight paths as x-rays do. Consequently, high-resolution tomography based on non-ionizing electromagnetic waves alone - such as confocal microscopy, two-photon microscopy, and optical coherence tomography - is limited to superficial imaging within approximately one optical transport mean free path (~1 mm in the skin) of the surface of scattering tissue. Ultrasonic imaging, on the contrary, provides good image resolution but suffers strong speckle artifacts as well as poor contrast in early-stage tumors. Ultrasound-mediated imaging modalities that combine electromagnetic and ultrasonic waves can synergistically overcome the above limitations. The hybrid modalities provide relatively deep penetration at high ultrasonic resolution and yield speckle-free images with high electromagnetic contrast.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/cleoe-iqec.2013.6801491DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 IEEE.
Record Number:CaltechAUTHORS:20190305-122048141
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190305-122048141
Official Citation:L. V. Wang and G. K. Beare, "Photoacoustic tomography: Ultrasonically breaking through the optical diffusion and diffraction limits," 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC, Munich, 2013, pp. 1-1. doi: 10.1109/CLEOE-IQEC.2013.6801491
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93527
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:05 Mar 2019 21:13
Last Modified:03 Oct 2019 20:55

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