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Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media

Wang, Lihong and Zhao, Xuemei (1997) Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media. Applied Optics, 36 (28). pp. 7277-7282. ISSN 0003-6935. https://resolver.caltech.edu/CaltechAUTHORS:20190305-153255323

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Abstract

Continuous-wave ultrasonic modulation of scattered laser light was used to image objects buried in tissue-simulating turbid media. The buried object had an absorption coefficient greater than the background turbid medium. The ultrasonic wave that was focused into the turbid media modulated the laser light that passed through the ultrasonic field. The modulated laser light that was collected by a photomultiplier tube reflected the local mechanical and optical properties in the zone of ultrasonic modulation. Objects buried in the middle plane of 5-cm-thick dense turbid media were imaged with millimeter resolution through the scanning and detecting alterations of the ultrasound-modulated optical signal. The optical properties of the dense turbid media included an absorption coefficient of 0.1 cm^(-1) and a reduced scattering coefficient of 10 cm^(-1) and were comparable with those of biological tissues in the visible and near-IR ranges. The dependence of the ultrasound-modulated optical signal on the off-axis distance of the detector from the optic axis and the area of the detector was studied as well.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1364/ao.36.007277DOIArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1997 Optical Society of America. Received 10 January 1997; revised manuscript received 19 May 1997. This project was sponsored in part by the National Institutes of Health grant R29 CA68562 and The Whitaker Foundation.
Funders:
Funding AgencyGrant Number
NIHR29 CA68562
Whitaker FoundationUNSPECIFIED
Subject Keywords:Ultrasonic modulation, acousto-optics, optical imaging, optical tomography, turbid media
Issue or Number:28
Record Number:CaltechAUTHORS:20190305-153255323
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190305-153255323
Official Citation:Lihong Wang and Xuemei Zhao, "Ultrasound-modulated optical tomography of absorbing objects buried in dense tissue-simulating turbid media," Appl. Opt. 36, 7277-7282 (1997)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93551
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:06 Mar 2019 00:00
Last Modified:03 Oct 2019 20:55

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