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Biological laser action

Wang, Lihong and Liu, Da and He, Nancy and Jacques, Steven L. and Thomsen, Sharon L. (1996) Biological laser action. Applied Optics, 35 (10). pp. 1775-1779. ISSN 0003-6935. doi:10.1364/ao.35.001775.

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The narrowing of the spectral linewidth and the increasing of the peak intensity characteristic of laser action were observed in emission spectra of dye-infused biological tissues. The tissue was infused with a solution of Rhodamine 640 perchlorate in ethanol and then excited with frequency-doubled Q-switched Nd:YAG laser pulses. The dependence of emission linewidth on the excitation radiant exposure and dye concentration was investigated. Laser action was also observed in biologically compatible fluorescein sodium dye dissolved in phosphate-buffered saline mixed with scattering polystyrene spheres. The sharp spectral peaks of laser action in tissues may find applications in the detection of superficial disease.

Item Type:Article
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URLURL TypeDescription
Wang, Lihong0000-0001-9783-4383
Additional Information:© 1996 Optical Society of America. Received 24 April 1995; revised manuscript received 23 August 1995. Thanks to L. Eppich for proofreading the manuscript. N. He, currently a student at Cornell University, thanks the C. B. & F. E. King's Foundation for supporting her summer program in our institution. The project was sponsored in part by The Whitaker Foundation, the National Institutes of Health, the U.S. Air Force Office of Scientific Research, and the Department of Energy.
Funding AgencyGrant Number
Whitaker FoundationUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Department of Energy (DOE)UNSPECIFIED
Subject Keywords:Tissue optics, laser action, fluorescence, amplification of spontaneous emission, turbid media
Issue or Number:10
Record Number:CaltechAUTHORS:20190305-153255411
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Official Citation:Lihong Wang, Da Liu, Nancy He, Steven L. Jacques, and Sharon L. Thomsen, "Biological laser action," Appl. Opt. 35, 1775-1779 (1996)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93552
Deposited By: George Porter
Deposited On:06 Mar 2019 15:32
Last Modified:16 Nov 2021 16:59

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