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The Neuropsychological Syndrome of Agenesis of the Corpus Callosum

Brown, Warren S. and Paul, Lynn K. (2019) The Neuropsychological Syndrome of Agenesis of the Corpus Callosum. Journal of the International Neuropsychological Society, 25 (3). pp. 324-330. ISSN 1355-6177.

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Background: Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum. Because the disorder can only be firmly diagnosed via neuroradiology, it has a short research history, and only recently has the cognitive syndrome become clear. Purpose: Our purpose is to review the primary deficits in AgCC that constitute the core syndrome. Conclusions: The cores syndrome includes: (1) reduced interhemispheric transfer of sensory-motor information; (2) reduced cognitive processing speed; and (3) deficits in complex reasoning and novel problem-solving. These domains do not appear to reflect different neuroanatomical abnormalities, but rather different domains of expression of reduced interhemispheric communication from callosal absence. Implications: These core deficits are expressed across various domains of cognitive, behavioral, and social functioning. The impact of these deficits varies across development and may be moderated by individual factors such as co-occurrence of other neurodevelopmental conditions, general intellectual capacity, and environmental support.

Item Type:Article
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URLURL TypeDescription
Brown, Warren S.0000-0001-6142-5588
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© The International Neuropsychological Society 2019. Published online: 29 January 2019. RECEIVED March 28, 2018; FINAL REVISION September 13, 2018; ACCEPTED November 5, 2018. The authors of this paper declare that they have no conflicts of interest with respect to the writing of this paper or the information contained. The writing of this paper was also not supported by grant funding.
Subject Keywords:Agenesis of the corpus callosum; Corpus callosum
Record Number:CaltechAUTHORS:20190311-142733872
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Official Citation:Brown, W., & Paul, L. (2019). The Neuropsychological Syndrome of Agenesis of the Corpus Callosum. Journal of the International Neuropsychological Society, 25(3), 324-330. doi:10.1017/S135561771800111X
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93694
Deposited By: Lynn Paul
Deposited On:11 Mar 2019 22:39
Last Modified:14 Mar 2019 23:05

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