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Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy

Paucek, Richard D. and Baltimore, David and Li, Guideng (2019) Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy. Trends in Immunology, 40 (4). pp. 292-309. ISSN 1471-4906. https://resolver.caltech.edu/CaltechAUTHORS:20190311-152538910

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Abstract

Immunotherapy treatments harnessing the patient’s immune system herald a new era of personalized medicine, offering hope for curative responses in patients with serious illnesses. Cell-mediated immunity can eliminate cancer cells and provide durable remissions. This often relies on repurposing cytotoxic T cell activity through modified T cell receptors or chimeric antigen receptors. Furthermore, synthetic biology has expanded the cell engineering toolkit to provide immune cells with more functionality, including disease targeting, potency, and safety. We focus on T cell-based immunotherapy, highlighting discoveries of genetic engineering and therapeutic use. We also examine emerging paths that could be undertaken to improve this novel class of drugs, and discuss the challenges of toxicities as well as other limitations of cellular immunotherapy.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.it.2019.02.002DOIArticle
ORCID:
AuthorORCID
Paucek, Richard D.0000-0002-4105-2443
Baltimore, David0000-0001-8723-8190
Li, Guideng0000-0003-0840-7262
Additional Information:© 2019 Elsevier. Available online 11 March 2019. We thank colleagues who commented on various sections of this article. Editorial assistance from C. Sacristán is much appreciated. Limitations on the number of references precluded us from citing many important contributions, and we appreciate the understanding of colleagues whose work could not be cited. The preparation of this review was supported by the University of California Los Angeles/California Institute of Technology Medical Scientist Training Program (R.D.P.), and the Parker Institute for Cancer Immunotherapy (G.L.).
Funders:
Funding AgencyGrant Number
UCLA/Caltech Medical Scientist Training Program UNSPECIFIED
Parker Institute for Cancer ImmunotherapyUNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20190311-152538910
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190311-152538910
Official Citation:Richard D. Paucek, David Baltimore, Guideng Li, The Cellular Immunotherapy Revolution: Arming the Immune System for Precision Therapy, Trends in Immunology, Volume 40, Issue 4, 2019, Pages 292-309, ISSN 1471-4906, https://doi.org/10.1016/j.it.2019.02.002. (http://www.sciencedirect.com/science/article/pii/S1471490619300250)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93704
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:11 Mar 2019 22:34
Last Modified:03 Oct 2019 20:56

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