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Robustness analysis of the heat shock response in E. coli

El-Samad, H. and Khammash, M. and Kurata, H. and Doyle, J. (2002) Robustness analysis of the heat shock response in E. coli. In: Proceedings of the 2002 American Control Conference. Vol.3. IEEE , Piscataway, NJ, pp. 1742-1747. ISBN 0-7803-7298-0.

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The bacterial heat shock response refers to the mechanism by which bacteria react to a sudden increase in the ambient temperature of growth. The consequences of such an unmediated temperature increase at the cellular level is the unfolding, misfolding, or aggregation of cell proteins, which threatens the life of the cell. Cells respond to the heat stress by initiating the production of heat-shock proteins whose function is to refold denatured proteins into their native states. The heat shock response, through the elevated synthesis of molecular chaperones and proteases, enables the repair of protein damage and the degradation of aggregated proteins. In a previous work (Kurata et al., 2001), we have devised a dynamic model for the heat shock response in E. coli. In the present paper, we provide a thorough discussion of the dynamical nature of this model. We use sensitivity analysis and simulation tools to illustrate the remarkable efficiency, robustness, and stability of the heat shock response system.

Item Type:Book Section
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El-Samad, H.0000-0001-6239-9916
Doyle, J.0000-0002-1828-2486
Additional Information:© 2002 IEEE. The authors would like to thank Carol Gross at the University of California at San Francisco for useful discussions and valuable insight into the heat shock response. The authors would also like to acknowledge support from the ISU SPRIGS Grant.
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Iowa State UniversityUNSPECIFIED
Record Number:CaltechAUTHORS:20190312-075150830
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Official Citation:H. El-Samad, M. Khammash, H. Kurata and J. Doyle, "Robustness analysis of the heat shock response in E. coli," Proceedings of the 2002 American Control Conference (IEEE Cat. No.CH37301), Anchorage, AK, USA, 2002, pp. 1742-1747 vol.3. doi: 10.1109/ACC.2002.1023817
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93715
Deposited By: Tony Diaz
Deposited On:12 Mar 2019 15:46
Last Modified:16 Nov 2021 17:00

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