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Neural Substrates of Emotion as Revealed by Functional Magnetic Resonance Imaging

Lee, Gregory P. and Meador, Kimford J. and Loring, David W. and Allison, Jerry D. and Brown, Warren S. and Paul, Lynn K. and Pillai, Jay J. and Lavin, Thomas B. (2004) Neural Substrates of Emotion as Revealed by Functional Magnetic Resonance Imaging. Cognitive and Behavioral Neurology, 17 (1). pp. 9-17. ISSN 1543-3633. doi:10.1097/00146965-200403000-00002.

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Objectives: To examine the brain circuitry involved in emotional experience and determine whether the cerebral hemispheres are specialized for positive and negative emotional experience. Background: Recent research has provided a preliminary sketch of the neurologic underpinnings of emotional processing involving specialized contributions of limbic and cortical brain regions. Electrophysiologic, functional imaging, and Wada test data have suggested positive, approach-related emotions are associated with left cerebral hemisphere regions, whereas negative, withdrawal-related emotions appear to be more aligned with right hemisphere mechanisms. Method: These emotional–neural associations were investigated using functional magnetic resonance imaging in 10 healthy controls with 20 positively and 20 negatively valenced pictures from the International Affective Picture System in a counterbalanced order. Pictures were viewed within a 1.5 Telsa scanner through computerized video goggles. Results: Emotional pictures resulted in significantly increased blood flow bilaterally in the mesial frontal lobe/anterior cingulate gyrus, dorsolateral frontal lobe, amygdala/anterior temporal regions, and cerebellum. Negative emotional pictures resulted in greater activation of the right hemisphere, and positive pictures caused greater activation of the left hemisphere. Conclusions: Results are consistent with theories emphasizing the importance of circuitry linking subcortical structures with mesial temporal, anterior cingulate, and frontal lobe regions in emotion and with the valence model of emotion that posits lateralized cerebral specialization for positive and negative emotional experience.

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Brown, Warren S.0000-0001-6142-5588
Paul, Lynn K.0000-0002-3128-8313
Additional Information:© 2004 Lippincott Williams & Wilkins, Inc. Received for publication March 10, 2003; revised September 2, 2003; accepted November 5, 2003.
Subject Keywords:emotion, functional magnetic resonance imaging, cerebral specialization, hemispheric specialization
Issue or Number:1
Record Number:CaltechAUTHORS:20190313-113037485
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93775
Deposited By: Katherine Johnson
Deposited On:13 Mar 2019 18:37
Last Modified:16 Nov 2021 17:00

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