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Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex

Chivukula, Srinivas and Jafari, Matiar and Aflalo, Tyson and Yong, Nicholas Au and Pouratian, Nader (2019) Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex. Frontiers in Neuroscience, 13 . Art. No. 140. ISSN 1662-453X. PMCID PMC6401528. https://resolver.caltech.edu/CaltechAUTHORS:20190314-105458079

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Abstract

Millions of people worldwide are afflicted with paralysis from a disruption of neural pathways between the brain and the muscles. Because their cortical architecture is often preserved, these patients are able to plan movements despite an inability to execute them. In such people, brain machine interfaces have great potential to restore lost function through neuroprosthetic devices, circumventing dysfunctional corticospinal circuitry. These devices have typically derived control signals from the motor cortex (M1) which provides information highly correlated with desired movement trajectories. However, sensorimotor control simultaneously engages multiple cognitive processes such as intent, state estimation, decision making, and the integration of multisensory feedback. As such, cortical association regions upstream of M1 such as the posterior parietal cortex (PPC) that are involved in higher order behaviors such as planning and learning, rather than in encoding movement itself, may enable enhanced, cognitive control of neuroprosthetics, termed cognitive neural prosthetics (CNPs). We illustrate in this review, through a small sampling, the cognitive functions encoded in the PPC and discuss their neural representation in the context of their relevance to motor neuroprosthetics. We aim to highlight through examples a role for cortical signals from the PPC in developing CNPs, and to inspire future avenues for exploration in their research and development.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.3389/fnins.2019.00140DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc6401528/PubMed CentralArticle
ORCID:
AuthorORCID
Jafari, Matiar0000-0002-2224-4896
Aflalo, Tyson0000-0002-0101-2455
Additional Information:© 2019 Chivukula, Jafari, Aflalo, Yong and Pouratian. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 31 December 2017. Accepted: 07 February 2019. Published: 27 February 2019. We would like to thank Professor Richard Andersen at the California Institute of Technology for reviewing this manuscript during its preparation and providing insightful feedback. Unrestricted philanthropic support provided by Casa Colina Centers for Rehabilitation to NP. SC is a recipient of a supervised research award from the National Institute of Health (NIH R25 NS079198). Author Contributions: SC was involved in the primary review of literature, the drafting of this manuscript in all its preparatory stages. TA, NY, and MJ contributed portions to the drafting of this manuscript and were instrumental in its review and improvement. NP provided invaluable guidance in the consolidation of ideas to be discussed in this manuscript and insightful reviews throughout its preparation. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
Casa Colina Centers for RehabilitationUNSPECIFIED
NIHR25 NS079198
Subject Keywords:posterior parietal cortex, peripersonal space, PPC, neuroprosthetics, motor, decision making, coordinate transformations
PubMed Central ID:PMC6401528
Record Number:CaltechAUTHORS:20190314-105458079
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190314-105458079
Official Citation:Chivukula S, Jafari M, Aflalo T, Yong NA and Pouratian N (2019) Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex. Front. Neurosci. 13:140. doi: 10.3389/fnins.2019.00140
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93801
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Mar 2019 18:09
Last Modified:18 Aug 2020 21:48

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