Lee, Changhyuk and Taal, Adriaan J. and Choi, Jaebin and Kim, Kukjoo and Tien, Kevin and Moreaux, Laurent C. and Roukes, Michael L. and Shepard, Kenneth L. (2019) A 512-Pixel 3kHz-Frame-Rate Dual-Shank Lensless Filterless Single-Photon-Avalanche-Diode CMOS Neural Imaging Probe. In: 2019 IEEE International Solid- State Circuits Conference - (ISSCC). IEEE , Piscataway, NJ, pp. 198-200. ISBN 978-1-5386-8531-0. https://resolver.caltech.edu/CaltechAUTHORS:20190314-133521536
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Abstract
Optical functional neural imaging has revolutionized neuroscience with optical reporters that enable single-cell-resolved monitoring of neuronal activity in vivo. State-of-the-art microscopy methods, however, are fundamentally limited in imaging depth by absorption and scattering in tissue even with the use of the most sophisticated two-photon microscopy techniques [1]. To overcome this imaging depth problem, we develop a lens-less, optical-filter-less, shank-based image sensor array that can be inserted into the brain, allowing cellular-resolution recording at arbitrary depths with excitation provided by an external laser light source (Fig. 11.5.1). Lens-less imaging is achieved generally by giving each pixel a spatial sensitivity function, which can be introduced by near-field or far-field, phase or amplitude masking. Since probe thickness must be less than 70μm to limit tissue damage and far-field masks are characterized by distances on the order of 200μm between the mask and the detector [2], we employ a near-field amplitude mask formed by Talbot gratings in the back-end metal of the CMOS process, which gives each pixel a diffraction-grating-induced angle-sensitivity [3]. Filter-less fluorescence imaging is achieved with time-gated operation in which the excitation light source is pulsed and pixel-level time-gated circuitry collects photons only after the excitation source has been removed.
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Additional Information: | © 2019 IEEE. This work was supported by the National Institutes of Health under Grant U01NS090596, by the Defense Advanced Research Projects Agency (DARPA) under Contract N66001-17-C-4012, and by the U. S. Army Research Laboratory and the U. S. Army Research Office under Contract W911NF-12-1-0594. We would also like to thank TSMC Foundry for their full support in testchip fabrication. | ||||||||||||||
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DOI: | 10.1109/ISSCC.2019.8662408 | ||||||||||||||
Record Number: | CaltechAUTHORS:20190314-133521536 | ||||||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190314-133521536 | ||||||||||||||
Official Citation: | C. Lee et al., "11.5 A 512-Pixel 3kHz-Frame-Rate Dual-Shank Lensless Filterless Single-Photon-Avalanche-Diode CMOS Neural Imaging Probe," 2019 IEEE International Solid- State Circuits Conference - (ISSCC), San Francisco, CA, USA, 2019, pp. 198-200. doi: 10.1109/ISSCC.2019.8662408 | ||||||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||||
ID Code: | 93826 | ||||||||||||||
Collection: | CaltechAUTHORS | ||||||||||||||
Deposited By: | Tony Diaz | ||||||||||||||
Deposited On: | 14 Mar 2019 20:44 | ||||||||||||||
Last Modified: | 16 Nov 2021 17:00 |
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