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Application of multivariable feedback methods to intravenous anesthetic pharmacodynamics

Dullerud, Geir and Csete, Marie and Doyle, John (1995) Application of multivariable feedback methods to intravenous anesthetic pharmacodynamics. In: 1995 American Control Conference. Vol.1. IEEE , Piscataway, NJ, pp. 791-795. ISBN 0-7803-2445-5.

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Continuous infusions of intravenous anesthetics are becoming increasingly popular during surgical procedures, largely because relatively precise, consistent control of anesthetic depth is possible over intravenous injection techniques. In this paper we investigate the main issues involved with the development of automatic intravenous anesthesia delivery systems in the context of robust multivariable control. We present a pharmacodynamic model that may be suitable for closed-loop control, and discuss clinical data collected from human subjects during actual surgical conditions with the anesthetic propofol.

Item Type:Book Section
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URLURL TypeDescription
Csete, Marie0000-0003-4591-0510
Doyle, John0000-0002-1828-2486
Additional Information:© 1995 IEEE. The authors are grateful to Dr. Stan Stead of UCLA Department of Anesthesiology for the computer equipment used during data collection.
Record Number:CaltechAUTHORS:20190318-102253057
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Official Citation:G. Dullerud, M. Csete and J. Doyle, "Application of multivariable feedback methods to intravenous anesthetic pharmacodynamics," Proceedings of 1995 American Control Conference - ACC'95, Seattle, WA, USA, 1995, pp. 791-795 vol.1. doi: 10.1109/ACC.1995.529765
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:93916
Deposited By: Tony Diaz
Deposited On:18 Mar 2019 17:58
Last Modified:16 Nov 2021 17:01

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