CaltechAUTHORS
  A Caltech Library Service

Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb

Sánchez-Guardado, Luis and Lois, Carlos (2019) Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20190322-081916788

[img] PDF - Submitted Version
Creative Commons Attribution.

2831Kb

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20190322-081916788

Abstract

Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to label neuronal progenitors sparsely and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/584805DOIDiscussion Paper
ORCID:
AuthorORCID
Lois, Carlos0000-0002-7305-2317
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license. We are grateful to Walter G. Gonzalez and Antuca Callejas for comments on the manuscript.
Subject Keywords:cell lineage, olfactory bulb, projection neurons, mitral cell, tufted cell, connectivity
Record Number:CaltechAUTHORS:20190322-081916788
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190322-081916788
Official Citation:Lineage does not regulate the connectivity of projection neurons in the mouse olfactory bulb Carlos Lois, Luis Sanchez-Guardado bioRxiv 584805; doi: https://doi.org/10.1101/584805
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94037
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:22 Mar 2019 15:39
Last Modified:22 Mar 2019 15:39

Repository Staff Only: item control page