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Deterministic lateral displacement MEMS device for continuous blood cell separation

Zheng, Siyang and Yung, Raylene and Tai, Yu-Chong and Kasdan, Harvey (2005) Deterministic lateral displacement MEMS device for continuous blood cell separation. In: 18th IEEE International Conference on Micro Electro Mechanical Systems. IEEE , Piscataway, NJ, pp. 851-854. ISBN 0-7803-8732-5. http://resolver.caltech.edu/CaltechAUTHORS:20190322-160107006

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Abstract

This work presents a new MEMS device which uses deterministic lateral displacement for the continuous separation of leukocytes (white blood cells) and erythrocytes (red blood cells). By running blood cells in laminar flow through an array of columnar obstacles, deterministic lateral displacement asserts that the path a cell follows is determined by its size. The system consists of PDMS channels with posts on glass slides. An effective separation region of 7 mm by 1.8 mm is achieved on a 1 cm by 1 cm chip. A 420 µm lateral separation was achieved for 5 µm and 10 µm beads. The critical particle size for separation was found experimentally to be 8 µm, concluded from our results using 5 µm, 7 µm, 8 µm and 10 µm polystyrene beads. Diluted whole blood and blood fraction of concentrated leukocytes were also tested with the devices in agreement with blood count results. Problem of blood cell stiction to device surfaces was investigated.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/MEMSYS.2005.1454063DOIArticle
ORCID:
AuthorORCID
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2005 IEEE. This work is supported by NASA through National Space Biomedical Research Institute (NSBFU). The co-operative agreement number is NCC 9-58-317.
Funders:
Funding AgencyGrant Number
NASANCC 9-58-317
Record Number:CaltechAUTHORS:20190322-160107006
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190322-160107006
Official Citation:Siyang Zheng, R. Yung, Yu-Chong Tai and H. Kasdan, "Deterministic lateral displacement MEMS device for continuous blood cell separation," 18th IEEE International Conference on Micro Electro Mechanical Systems, 2005. MEMS 2005., Miami Beach, FL, USA, 2005, pp. 851-854. doi: 10.1109/MEMSYS.2005.1454063
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94079
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Mar 2019 23:06
Last Modified:22 Mar 2019 23:06

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