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Progress toward the total synthesis of falcatin A

Mendoza, Skyler Dakota and Reisman, Sarah E. (2019) Progress toward the total synthesis of falcatin A. In: 257th ACS National Meeting & Exposition, 31 March - 4 April 2019, Orlando, FL.

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GIRK channels (G protein mediated inwardly-rectifying potassium ion channels) have been shown to regulate the elec. activity of several cell types including neurons, cardiac atrial myocytes, and b-pancreatic cells. As such, the malfunction of GIRK channels has also been implicated in disorders such as neuropathic pain, drug addiction, and cardiac arrhythmias. Falcatin A is a myrsinane diterpenoid that possesses inhibitory activity against GIRK channels with an IC50 value of 2.5 ± 0.2 uM. We hypothesize that the 5/7/6 carbocyclic framework of the natural product could be constructed in a single step through a combination of hydrogen bonding, hydrogen atom transfer, and photoredox catalysis to bring together two complex fragments in a convergent coupling strategy, allowing for the rapid and efficient synthesis of falcatin A and analogs. The synthesis and studies of falcatin A and its analogs could potentially provide some insight into the modulation of GIRK channels. Herein, we describe our synthetic progress toward the total synthesis of falcatin A.

Item Type:Conference or Workshop Item (Paper)
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Reisman, Sarah E.0000-0001-8244-9300
Additional Information:© 2019 American Chemical Society.
Record Number:CaltechAUTHORS:20190325-091013157
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94098
Deposited By: Tony Diaz
Deposited On:25 Mar 2019 16:12
Last Modified:03 Oct 2019 21:00

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