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Analysis and design of a synthetic transcriptional network for exact adaptation

Kim, Jongmin and Murray, Richard M. (2011) Analysis and design of a synthetic transcriptional network for exact adaptation. In: 2011 IEEE Biomedical Circuits and Systems Conference (BioCAS). IEEE , Piscataway, NJ, pp. 345-348. ISBN 9781457714702. https://resolver.caltech.edu/CaltechAUTHORS:20190326-141247494

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Abstract

This paper presents a mathematical model for a synthetic transcriptional regulatory network in vitro. This circuit design resembles one of the well-known network motifs, the incoherent feed-forward loop, in which an activator regulates both a gene and a repressor of the gene. Through mathematical analysis, we show how the circuit can be controlled to demonstrate exact adaptation to input signals.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1109/biocas.2011.6107798DOIArticle
ORCID:
AuthorORCID
Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2011 IEEE. We thank Elisa Franco and Enoch Yeung for discussion.
Record Number:CaltechAUTHORS:20190326-141247494
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190326-141247494
Official Citation:J. Kim and R. M. Murray, "Analysis and design of a synthetic transcriptional network for exact adaptation," 2011 IEEE Biomedical Circuits and Systems Conference (BioCAS), San Diego, CA, 2011, pp. 345-348. doi: 10.1109/BioCAS.2011.6107798
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94155
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:27 Mar 2019 14:44
Last Modified:03 Oct 2019 21:01

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