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Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex

Iigaya, Kiyohito and Hauser, Tobias U. and Kurth-Nelson, Zeb and O’Doherty, John P. and Dayan, Peter and Dolan, Raymond J. (2019) Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex. . (Unpublished) http://resolver.caltech.edu/CaltechAUTHORS:20190327-110036647

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Abstract

Having something to look forward to is a keystone of well-being. Anticipation of a future reward, like an upcoming vacation, can be more gratifying than the experience of reward itself. Theories of anticipation have described how it causes behaviors ranging from beneficial information-seeking to harmful addiction. Here, we investigated how the brain generates and enhances anticipatory pleasure, by analyzing brain activity of human participants who received information predictive of future pleasant outcomes in a decision-making task. Using a computational model of anticipation, we show that three regions orchestrate anticipatory pleasure. We show ventromedial prefrontal cortex (vmPFC) tracks the value of anticipation; dopaminergic midbrain responds to information that enhances anticipation, while the sustained activity in hippocampus provides for functional coupling between these regions. This coordinating role for hippocampus is consistent with its known role in the vivid imagination of future outcomes. Our findings throw new light on the neural underpinnings of how anticipation influences decision-making, while also unifying a range of phenomena associated with risk and time-delay preference.


Item Type:Report or Paper (Discussion Paper)
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/588699DOIDiscussion Paper
https://www.biorxiv.org/content/10.1101/588699v1OrganizationDiscussion Paper
ORCID:
AuthorORCID
Iigaya, Kiyohito0000-0002-4748-8432
Dayan, Peter0000-0003-3476-1839
Additional Information:The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. bioRxiv preprint first posted online Mar. 26, 2019. We thank Tim Behrens for his insightful suggestion for the Fourier phase randomization test. We thank Colin Camerer, George Loewenstein, Sandro Romani, Ethan Bromberg-Martin, Jackie Gotlieb, Elliot Ludvig, Yunzhe Liu, Bastian Blain, Giles Story, Laurence Hunt, Jeff Cockburn, Vincent Man, Tomas Aquiono, Caroline Charpentier, Bowen Fung, Wolfgang Pauli, Erin Burkett for the most valuable discussions and helpful suggestions for the manuscript. We also thank radiographers at the UCL for their assistance in running fMRI experiments. This work was supported by the Max Planck Society, the Gatsby Foundation, Wellcome Trust Investigator Award, Japan Society for the Promotion of Science, the Swartz Foundation, Wellcome Sir Henry Dale Fellowship (211155/Z/18/Z), the Jacobs Foundation (2017-1261-04), the Medical Research Foundation, and 2018 NARSAD Young Investigator grant (27023) from the Brain & Behavior Research Foundation.
Funders:
Funding AgencyGrant Number
Max Planck SocietyUNSPECIFIED
Gatsby FoundationUNSPECIFIED
Wellcome TrustUNSPECIFIED
Japan Society for the Promotion of Science (JSPS)UNSPECIFIED
Swartz FoundationUNSPECIFIED
Wellcome Sir Henry Dale Fellowship211155/Z/18/Z
Jacobs Foundation2017-1261-04
Ellison Medical FoundationUNSPECIFIED
Brain and Behavior Research Foundation27023
Record Number:CaltechAUTHORS:20190327-110036647
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190327-110036647
Official Citation:Hippocampal-midbrain circuit enhances the pleasure of anticipation in the prefrontal cortex. Kiyohito Iigaya, Tobias U. Hauser, Zeb Kurth-Nelson, John P O'Doherty, Peter Dayan, Raymond J Dolan. bioRxiv 588699; doi: https://doi.org/10.1101/588699
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94211
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:27 Mar 2019 18:09
Last Modified:27 Mar 2019 18:09

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