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Modeling of Collective Cell Behaviors Interacting With Extracellular Matrix Using Dual Faceted Linearization

Mayalu, Michaëlle N. and Kim, Min-Cheol and Asada, Haruhiko (2018) Modeling of Collective Cell Behaviors Interacting With Extracellular Matrix Using Dual Faceted Linearization. In: 2018 ASME Dynamic Systems and Control Conference. Vol.1. American Society of Mechanical Engineers , New York, NY, Art. No. V001T14A005. ISBN 978-0-7918-5189-0. http://resolver.caltech.edu/CaltechAUTHORS:20190402-131700269

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Abstract

Cells interacting over an extracellular matrix (ECM) exhibit emergent behaviors, which are often observably different from single-cell dynamics. Fibroblasts embedded in a 3-D ECM, for example, compact the surrounding gel and generate an anisotropic strain field, which cannot be observed in single cell-induced gel compaction. This emergent matrix behavior results from collective intracellular mechanical interaction and is crucial to explain the large deformations and mechanical tensions that occur during embryogenesis, tissue development and wound healing. Prediction of multi-cellular interactions entails nonlinear dynamic simulation, which is prohibitively complex to compute using first principles especially as the number of cells increase. Here, we introduce a new methodology for predicting nonlinear behaviors of multiple cells interacting mechanically through a 3D ECM. In the proposed method, we first apply Dual-Faceted Linearization to nonlinear dynamic systems describing cell/matrix behavior. Using this unique linearization method, the original nonlinear state equations can be expressed with a pair of linear dynamic equations by augmenting the independent state variables with auxiliary variables which are nonlinearly dependent on the original states. Furthermore, we can find a reduced order latent space representation of the dynamic equations by orthogonal projection onto the basis of a lower dimensional linear manifold within the augmented variable space. Once converted to latent variable equations, we superpose multiple dynamic systems to predict their collective behaviors. The method is computationally efficient and accurate as demonstrated through its application for prediction of emergent cell induced ECM compaction.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1115/DSCC2018-9164DOIArticle
ORCID:
AuthorORCID
Mayalu, Michaëlle N.0000-0002-9678-0157
Kim, Min-Cheol0000-0001-6649-9463
Additional Information:© 2018 by ASME. Paper No. DSCC2018-9164.
Subject Keywords:Modeling, Compacting, Equations of motion, Biological tissues, Dynamic systems, Anisotropy, Dynamics (Mechanics), Deformation, Simulation, Manifolds
Record Number:CaltechAUTHORS:20190402-131700269
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190402-131700269
Official Citation:Mayalu MN, Kim M, Asada H. Modeling of Collective Cell Behaviors Interacting With Extracellular Matrix Using Dual Faceted Linearization. ASME. Dynamic Systems and Control Conference, Volume 1: Advances in Control Design Methods; Advances in Nonlinear Control; Advances in Robotics; Assistive and Rehabilitation Robotics; Automotive Dynamics and Emerging Powertrain Technologies; Automotive Systems; Bio Engineering Applications; Bio-Mechatronics and Physical Human Robot Interaction; Biomedical and Neural Systems; Biomedical and Neural Systems Modeling, Diagnostics, and Healthcare ():V001T14A005. doi:10.1115/DSCC2018-9164.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94368
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 Apr 2019 20:24
Last Modified:02 Apr 2019 20:24

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