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Feedback architectures to regulate flux of components in artificial gene networks

Giordano, Giulia and Franco, Elisa and Murray, Richard M. (2013) Feedback architectures to regulate flux of components in artificial gene networks. In: 2013 American Control Conference. IEEE , Piscataway, NJ, pp. 4747-4752. ISBN 978-1-4799-0177-7.

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This paper focuses on the regulation of RNA production for in vitro synthetic gene networks. We consider the problem of matching the production rate of several RNA species concurrently transcribed to form RNA complexes. We design regulatory feedback loops based on two schemes: negative auto-regulation (which can minimize the potentially harmful amount of molecules not used to form products) and cross-activation (which can maximize the overall output flux). We analyze numerically the performance of these schemes: in both cases, transcription rate matching can be achieved through proper feedback constants; negative feedback is faster and maintains stability. A possible experimental implementation of a three and four genes negative feedback architecture is also numerically studied.

Item Type:Book Section
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URLURL TypeDescription
Franco, Elisa0000-0003-1103-2668
Murray, Richard M.0000-0002-5785-7481
Additional Information:© 2013 IEEE. The authors acknowledge financial support by the National Science Foundation (NSF) grant CCF-0832824 (The Molecular Programming Project) and the Bourns College of Engineering at UC Riverside.
Funding AgencyGrant Number
University of California, RiversideUNSPECIFIED
Record Number:CaltechAUTHORS:20190403-105326642
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Official Citation:G. Giordano, E. Franco and R. M. Murray, "Feedback architectures to regulate flux of components in artificial gene networks," 2013 American Control Conference, Washington, DC, 2013, pp. 4747-4752. doi: 10.1109/ACC.2013.6580572
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94402
Deposited By: Tony Diaz
Deposited On:03 Apr 2019 18:18
Last Modified:16 Nov 2021 17:04

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