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Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application

Bi, Renzhe and Balasundaram, Ghayathri and Dinish, U. S. and Jeon, Seungwan and Imai, Toru and Pu, Yang and Ng, Lai Guan and Kim, Chulhong and Wang, Lihong and Olivo, Malini (2019) Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application. In: Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis. Proceedings of SPIE. No.10873. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 108730B. ISBN 9781510623880. https://resolver.caltech.edu/CaltechAUTHORS:20190404-110210209

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Abstract

The hemodynamics and oxygen saturation status of vascular are very important biomarkers for disease, such as brain glioma tumor and ischemia-reperfusion ulcer. Therefore, a high spatial resolution imaging tool for vascular imaging is demanded. Conventional optical imaging modalities, including confocal microscopy and two-photon microscopy, require external contrast agent to image blood vessels and are not sensitive to oxygen saturation. The development of photoacoustic microscopy provides a contrast-free, high-spatial resolution and functional vascular imaging tool. It’s gaining more and more popularity in biomedical research. In this paper, we introduce a dual-wavelength opticalresolution photoacoustic microscopy (OR-PAM) system for functional imaging of vasculature. This system has demonstrated its application in brain glioma tumor imaging, as well as skin ischemia-reperfusion imaging.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2507355DOIArticle
ORCID:
AuthorORCID
Imai, Toru0000-0002-9497-8549
Wang, Lihong0000-0001-9783-4383
Additional Information:© 2019 Society of Photo-optical Instrumentation Engineers (SPIE).
Subject Keywords:Photoacoustic microscopy, functional imaging, biomedical imaging, vascular imaging
Series Name:Proceedings of SPIE
Issue or Number:10873
Record Number:CaltechAUTHORS:20190404-110210209
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190404-110210209
Official Citation:Renzhe Bi, Ghayathri Balasundaram, Dinish U.S., Seungwan Jeon, Toru Imai, Yang Pu, Lai Guan Ng, Chulhong Kim, Lihong Wang, and Malini Olivo "Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730B (4 March 2019); doi: 10.1117/12.2507355; https://doi.org/10.1117/12.2507355
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94456
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2019 18:21
Last Modified:03 Oct 2019 21:04

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