Bi, Renzhe and Balasundaram, Ghayathri and Dinish, U. S. and Jeon, Seungwan and Imai, Toru and Pu, Yang and Ng, Lai Guan and Kim, Chulhong and Wang, Lihong and Olivo, Malini (2019) Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application. In: Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis. Proceedings of SPIE. No.10873. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 108730B. ISBN 9781510623880. https://resolver.caltech.edu/CaltechAUTHORS:20190404-110210209
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Abstract
The hemodynamics and oxygen saturation status of vascular are very important biomarkers for disease, such as brain glioma tumor and ischemia-reperfusion ulcer. Therefore, a high spatial resolution imaging tool for vascular imaging is demanded. Conventional optical imaging modalities, including confocal microscopy and two-photon microscopy, require external contrast agent to image blood vessels and are not sensitive to oxygen saturation. The development of photoacoustic microscopy provides a contrast-free, high-spatial resolution and functional vascular imaging tool. It’s gaining more and more popularity in biomedical research. In this paper, we introduce a dual-wavelength opticalresolution photoacoustic microscopy (OR-PAM) system for functional imaging of vasculature. This system has demonstrated its application in brain glioma tumor imaging, as well as skin ischemia-reperfusion imaging.
Item Type: | Book Section | ||||||
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Additional Information: | © 2019 Society of Photo-optical Instrumentation Engineers (SPIE). | ||||||
Subject Keywords: | Photoacoustic microscopy, functional imaging, biomedical imaging, vascular imaging | ||||||
Series Name: | Proceedings of SPIE | ||||||
Issue or Number: | 10873 | ||||||
DOI: | 10.1117/12.2507355 | ||||||
Record Number: | CaltechAUTHORS:20190404-110210209 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20190404-110210209 | ||||||
Official Citation: | Renzhe Bi, Ghayathri Balasundaram, Dinish U.S., Seungwan Jeon, Toru Imai, Yang Pu, Lai Guan Ng, Chulhong Kim, Lihong Wang, and Malini Olivo "Functional vascular imaging by Photoacoustic Microscopy (PAM) and its biomedical application", Proc. SPIE 10873, Optical Biopsy XVII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 108730B (4 March 2019); doi: 10.1117/12.2507355; https://doi.org/10.1117/12.2507355 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 94456 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Tony Diaz | ||||||
Deposited On: | 04 Apr 2019 18:21 | ||||||
Last Modified: | 16 Nov 2021 17:05 |
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