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Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)

Li, Yang and Wong, Terence T. W. and Shi, Junhui and Hsu, Hsun-Chia and Wang, Lihong V. (2019) Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation). In: Photons Plus Ultrasound: Imaging and Sensing 2019. Proceedings of SPIE. No.10878. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 108781C. ISBN 9781510623989.

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To date, most optical-resolution photoacoustic microscopy (OR-PAM) systems rely on mechanical scanning with confocally aligned optical excitation and ultrasonic detection. As a result, the imaging speed of these systems is limited by the scanning speed. Although several multifocal OR-PA computed tomography (MFOR-PACT) systems had been developed to address this limitation, they were hindered by the complex design in a constrained physical space. Here, we present a two-dimensional (2D) MFOR-PAM system based on a 2D microlens array and an acoustic ergodic relay. This system is able to detect PA signals generated from 400 optical foci in parallel with a single-element transducer, and then raster scan the optical foci patterns to form an image. This system has improved the imaging resolution of a conventional photoacoustic ergodic relay system from 220 μm to 13 μm. Moreover, this system has reduced the imaging time of a conventional OR-PAM system at the same resolution and laser repetition rate by 400 times. We demonstrated the ability of the system with both in vitro and in vivo experiments.

Item Type:Book Section
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URLURL TypeDescription ItemJournal Article
Li, Yang0000-0002-4939-8174
Wong, Terence T. W.0000-0001-6399-758X
Shi, Junhui0000-0002-5741-2781
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2019 Society of Photo-optical Instrumentation Engineers (SPIE).
Series Name:Proceedings of SPIE
Issue or Number:10878
Record Number:CaltechAUTHORS:20190404-150016451
Persistent URL:
Official Citation:Yang Li, Terence T. W. Wong, Junhui Shi, Hsun-Chia Hsu, and Lihong V. Wang "Multifocal photoacoustic microscopy through an ergodic relay (Conference Presentation)", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108781C (4 March 2019); doi: 10.1117/12.2513502;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94472
Deposited By: Tony Diaz
Deposited On:04 Apr 2019 22:07
Last Modified:16 Nov 2021 17:05

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