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Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)

Liu, Yan and Shen, Yuecheng and Ruan, Haowen and Brodie, Frank L. and Wong, Terence T. W. and Yang, Changhuei and Wang, Lihong V. (2019) Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation). In: Adaptive Optics and Wavefront Control for Biological Systems V. Proceedings of SPIE. No.10886. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 1088602. ISBN 9781510624146. http://resolver.caltech.edu/CaltechAUTHORS:20190404-151930944

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Abstract

Normal development of the visual system in infants relies on clear images being projected onto the retina, which can be disrupted by lens opacity caused by congenital cataract. This disruption, if uncorrected in early life, results in amblyopia (permanently decreased vision even after removal of the cataract). Doctors are able to prevent amblyopia by removing the cataract during the first several weeks of life, but this surgery risks a host of complications which can be equally visually disabling. Here, we investigated the feasibility of focusing light noninvasively through highly scattering cataractous lenses to stimulate the retina, thereby preventing amblyopia. This approach would allow the cataractous lens removal surgery to be delayed and hence greatly reduce the risk of complications from early surgery. Employing a wavefront shaping technique named time-reversed ultrasonically encoded (TRUE) optical focusing in reflection mode, we focused 532 nm light through a highly scattering ex vivo adult human cataractous lens of 112 mean free path thick. This work demonstrates a potential clinical application of wavefront shaping techniques.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2508994DOIArticle
ORCID:
AuthorORCID
Shen, Yuecheng0000-0003-1990-8142
Wong, Terence T. W.0000-0001-6399-758X
Yang, Changhuei0000-0001-8791-0354
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2019 Society of Photo-optical Instrumentation Engineers (SPIE).
Record Number:CaltechAUTHORS:20190404-151930944
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190404-151930944
Official Citation:Yan Liu, Yuecheng Shen, Haowen Ruan, Frank L. Brodie, Terence T. W. Wong, Changhuei Yang, and Lihong V. Wang "Time-reversed ultrasonically encoded (TRUE) optical focusing through highly scattering ex vivo human cataractous lenses for congenital cataract treatment (Conference Presentation)", Proc. SPIE 10886, Adaptive Optics and Wavefront Control for Biological Systems V, 1088602 (4 March 2019); doi: 10.1117/12.2508994; https://doi.org/10.1117/12.2508994
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94475
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2019 23:41
Last Modified:04 Apr 2019 23:41

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