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Exponential path of photoacoustic tomography to the largest conference at Photonics West: omniscale imaging from organelles to organisms (Conference Presentation)

Wang, Lihong V. (2019) Exponential path of photoacoustic tomography to the largest conference at Photonics West: omniscale imaging from organelles to organisms (Conference Presentation). In: Photons Plus Ultrasound: Imaging and Sensing 2019. Proceedings of SPIE. No.10878. Society of Photo-optical Instrumentation Engineers (SPIE) , Bellingham, WA, Art. No. 108780W. ISBN 9781510623989. https://resolver.caltech.edu/CaltechAUTHORS:20190404-152902324

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Abstract

Photoacoustic tomography has been developed for in vivo functional, metabolic, molecular, and histologic imaging by physically combining optical and ultrasonic waves. Broad applications include early-cancer detection and brain imaging. High-resolution optical imaging—such as confocal microscopy, two-photon microscopy, and optical coherence tomography—is limited to superficial imaging within the optical diffusion limit (~1 mm in the skin) of the surface of scattering tissue. By synergistically combining light and sound, photoacoustic tomography conquers the optical diffusion limit and provides deep penetration at high ultrasonic resolution and high optical contrast. Photoacoustic tomography has two major embodiments: photoacoustic computed tomography and photoacoustic microscopy. In photoacoustic computed tomography, a pulsed broad laser beam illuminates the biological tissue to generate a small but rapid temperature rise, which leads to emission of ultrasonic waves due to thermoelastic expansion. The unscattered pulsed ultrasonic waves are then detected by ultrasonic transducers. High-resolution tomographic images of optical contrast are then formed through image reconstruction. In photoacoustic microscopy, a pulsed laser beam is delivered into the biological tissue to generate ultrasonic waves, which are then detected with a focused ultrasonic transducer to form a depth resolved 1D image. Raster scanning yields 3D high-resolution tomographic images. Super-depths beyond the optical diffusion limit have been reached with high spatial resolution. The annual conference on PAT has grown exponentially since early 2000 and become the largest in SPIE’s 20,000-attendee Photonics West since 2010.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1117/12.2515432DOIArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2019 Society of Photo-optical Instrumentation Engineers (SPIE).
Series Name:Proceedings of SPIE
Issue or Number:10878
Record Number:CaltechAUTHORS:20190404-152902324
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190404-152902324
Official Citation:Lihong V. Wang "Exponential path of photoacoustic tomography to the largest conference at Photonics West: omniscale imaging from organelles to organisms (Conference Presentation)", Proc. SPIE 10878, Photons Plus Ultrasound: Imaging and Sensing 2019, 108780W (4 March 2019); doi: 10.1117/12.2515432; https://doi.org/10.1117/12.2515432
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94476
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 Apr 2019 23:12
Last Modified:03 Oct 2019 21:04

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