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Deconstructing and reconstructing the mouse and human early embryo

Shahbazi, Marta N. and Zernicka-Goetz, Magdalena (2018) Deconstructing and reconstructing the mouse and human early embryo. Nature Cell Biology, 20 (8). pp. 878-887. ISSN 1465-7392. https://resolver.caltech.edu/CaltechAUTHORS:20190405-170314164

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Abstract

The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1038/s41556-018-0144-xDOIArticle
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ORCID:
AuthorORCID
Shahbazi, Marta N.0000-0002-1599-5747
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2018 Springer Nature Publishing AG. Received: 19 January 2018; Accepted: 15 June 2018; Published online: 23 July 2018. We apologize to our colleagues whose findings we could not cite due to space constraints. We are grateful to S.E. Harrison, M. Zhu, F. Antonica and M. Petruzzelli for their insightful comments. The M.Z-G lab is supported by grants from the European Research Council (669198) and the Wellcome Trust (098287/Z/12/Z). M. Shahbazi is supported by an Early Career Leverhulme Trust fellowship. The authors declare no competing interests.
Funders:
Funding AgencyGrant Number
European Research Council (ERC)669198
Wellcome Trust098287/Z/12/Z
Leverhulme TrustUNSPECIFIED
Issue or Number:8
Record Number:CaltechAUTHORS:20190405-170314164
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190405-170314164
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94528
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Apr 2019 15:42
Last Modified:03 Oct 2019 21:04

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