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The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?

Graham, Sarah J. L. and Zernicka-Goetz, Magdalena (2016) The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous? In: Essays on Developmental Biology, Part B. Current Topics in Developmental Biology. No.117. Elsevier , New York, NY, pp. 671-695. ISBN 9780128013823. http://resolver.caltech.edu/CaltechAUTHORS:20190405-170315260

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Abstract

Specification of cell fate in the early mouse embryo involves the generation of heterogeneities between cells in polarity, position, gene expression, and protein activity. Identifying when and how these differences first become established represents an important challenge for understanding the roles of stochastic and cell history-dependent mechanisms in mammalian development.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/bs.ctdb.2015.11.021DOIArticle
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2016 Elsevier. Available online 21 January 2016. We thank the Wellcome Trust for supporting the work in our laboratory and Meng Zhu for comments on the manuscript.
Funders:
Funding AgencyGrant Number
Wellcome TrustUNSPECIFIED
Subject Keywords:Mouse embryo; Preimplantation; Blastocyst; Cell fate; Differentiation; Pluripotency
Record Number:CaltechAUTHORS:20190405-170315260
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190405-170315260
Official Citation:Sarah J.L. Graham, Magdalena Zernicka-Goetz, Chapter Thirty-Nine - The Acquisition of Cell Fate in Mouse Development: How Do Cells First Become Heterogeneous?, Editor(s): Paul M. Wassarman, Current Topics in Developmental Biology, Academic Press, Volume 117, 2016, Pages 671-695, ISSN 0070-2153, ISBN 9780128013823, https://doi.org/10.1016/bs.ctdb.2015.11.021. (http://www.sciencedirect.com/science/article/pii/S0070215315001878)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94539
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Apr 2019 21:19
Last Modified:09 Apr 2019 21:19

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