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Mapping the journey from totipotency to lineage specification in the mouse embryo

Leung, Chuen Yan and Zernicka-Goetz, Magdalena (2015) Mapping the journey from totipotency to lineage specification in the mouse embryo. Current Opinion in Genetics and Development, 34 . pp. 71-76. ISSN 0959-437X. doi:10.1016/j.gde.2015.08.002. https://resolver.caltech.edu/CaltechAUTHORS:20190405-170315620

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Abstract

Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryogenesis. The first decisions are made as the embryo prepares for implantation, a process that will require specialization of extra-embryonic lineages while preserving an embryonic one. In this mini-review, we will focus on the mouse as a mammalian model and discuss recent advances in the decision making process of the early embryo.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.gde.2015.08.002DOIArticle
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2015 The Authors. Published by Elsevier. Under a Creative Commons license (Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)) Available online 3 September 2015. We are grateful to the Wellcome Trust for supporting the research in our group.
Funders:
Funding AgencyGrant Number
Wellcome TrustUNSPECIFIED
DOI:10.1016/j.gde.2015.08.002
Record Number:CaltechAUTHORS:20190405-170315620
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190405-170315620
Official Citation:Chuen Yan Leung, Magdalena Zernicka-Goetz, Mapping the journey from totipotency to lineage specification in the mouse embryo, Current Opinion in Genetics & Development, Volume 34, 2015, Pages 71-76, ISSN 0959-437X, https://doi.org/10.1016/j.gde.2015.08.002. (http://www.sciencedirect.com/science/article/pii/S0959437X15000854)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94542
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Apr 2019 21:49
Last Modified:16 Nov 2021 17:05

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