A Caltech Library Service

Cell death and morphogenesis during early mouse development: Are they interconnected?

Bedzhov, Ivan and Zernicka-Goetz, Magdalena (2015) Cell death and morphogenesis during early mouse development: Are they interconnected? Bioessays, 37 (4). pp. 372-378. ISSN 0265-9247. PMCID PMC4409078. doi:10.1002/bies.201400147.

[img] PDF - Published Version
Creative Commons Attribution.


Use this Persistent URL to link to this item:


Shortly after implantation the embryonic lineage transforms from a coherent ball of cells into polarized cup shaped epithelium. Recently we elucidated a previously unknown apoptosis‐independent morphogenic event that reorganizes the pluripotent lineage. Polarization cues from the surrounding basement membrane rearrange the epiblast into a polarized rosette‐like structure, where subsequently a central lumen is established. Thus, we provided a new model revising the current concept of apoptosis‐dependent epiblast morphogenesis. Cell death however has to be tightly regulated during embryogenesis to ensure developmental success. Here, we follow the stages of early mouse development and take a glimpse at the critical signaling and morphogenic events that determine cells destiny and reshape the embryonic lineage.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2015 The Authors. Bioessays published by WILEY Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Version of Record online: 15 January 2015. We are grateful to Sarah Graham for the valuable feedback on the manuscript and to the Wellcome Trust for supporting the research in our group. The authors have declared no conflict of interest.
Funding AgencyGrant Number
Subject Keywords:apoptosis, blastocyst, egg cylinder, epiblast, implantation, morphogenesis
Issue or Number:4
PubMed Central ID:PMC4409078
Record Number:CaltechAUTHORS:20190405-170315955
Persistent URL:
Official Citation:Bedzhov, I. and Zernicka‐Goetz, M. (2015), Cell death and morphogenesis during early mouse development: Are they interconnected?. BioEssays, 37: 372-378. doi:10.1002/bies.201400147
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94545
Deposited By: George Porter
Deposited On:09 Apr 2019 22:46
Last Modified:16 Nov 2021 17:05

Repository Staff Only: item control page