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Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress

Zelikowsky, Moriel and Ding, Keke and Anderson, David J. (2018) Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress. Cold Spring Harbor Symposia on Quantitative Biology, 83 . pp. 97-103. ISSN 0091-7451. https://resolver.caltech.edu/CaltechAUTHORS:20190409-111444565

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Abstract

Prolonged periods of social isolation can generate an internal state that exerts profound effects on the brain and behavior. However, the neurobiological underpinnings of protracted social isolation have been relatively understudied. Here, we review recent literature implicating peptide neuromodulators in the establishment and maintenance of such internal states. More specifically, we describe an evolutionarily conserved role for the neuropeptide tachykinin in the control of social isolation–induced aggression and review recent data that elucidate the manner by which Tac2 controls the widespread effects of social isolation on behavior in mice. Last, we discuss potential roles for additional neuromodulators in controlling social isolation and a more general role for Tac2 in the response to other forms of stress.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1101/sqb.2018.83.038109DOIArticle
ORCID:
AuthorORCID
Ding, Keke0000-0002-5261-4843
Anderson, David J.0000-0001-6175-3872
Additional Information:© 2018 Zelikowsky et al. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited. Published by Cold Spring Harbor Laboratory Press.
Record Number:CaltechAUTHORS:20190409-111444565
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190409-111444565
Official Citation:Neuropeptidergic Control of an Internal Brain State Produced by Prolonged Social Isolation Stress Moriel Zelikowsky, Keke Ding, and David J. Anderson Cold Spring Harb Symp Quant Biol 2018 83: 97-103; Published in Advance April 4, 2019, doi:10.1101/sqb.2018.83.038109
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94585
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Apr 2019 18:28
Last Modified:09 Mar 2020 13:18

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