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Polarity in Cell-Fate Acquisition in the Early Mouse Embryo

Leung, C. Y. and Zhu, M. and Zernicka-Goetz, M. (2016) Polarity in Cell-Fate Acquisition in the Early Mouse Embryo. In: Mammalian Preimplantation Development. Current Topics in Developmental Biology. No.120. Elsevier , New York, NY, pp. 203-234. ISBN 9780128014288.

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Establishing polarity is a fundamental part of embryogenesis and can be traced back to the earliest developmental stages. It can be achieved in one of two ways: through the preexisting polarization of germ cells before fertilization or via symmetry breaking after fertilization. In mammals, it seems to be the latter, and we will discuss the various cytological and molecular events that lead up to this event, its mechanisms and the consequences. In mammals, the first polarization event occurs in the preimplantation period, when the embryo is but a cluster of cells, free-floating in the oviduct. This provides a unique, autonomous system to study the de novo polarization that is essential to life. In this review, we will cover modern and past studies on the polarization of the early embryo, using the mouse as a model system, as well as hypothesizing the potential implications and functions of the biological events involved.

Item Type:Book Section
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Zhu, M.0000-0001-6157-8840
Zernicka-Goetz, M.0000-0002-7004-2471
Additional Information:© 2016 Elsevier. Available online 7 June 2016.
Subject Keywords:Preimplantation embryo; Polarity; Pluripotency; Heterogeneity; Par complex
Series Name:Current Topics in Developmental Biology
Issue or Number:120
Record Number:CaltechAUTHORS:20190409-140137785
Persistent URL:
Official Citation:C.Y. Leung, M. Zhu, M. Zernicka-Goetz, Chapter Six - Polarity in Cell-Fate Acquisition in the Early Mouse Embryo, Editor(s): Melvin L. DePamphilis, Current Topics in Developmental Biology, Academic Press, Volume 120, 2016, Pages 203-234, ISSN 0070-2153, ISBN 9780128014288, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94599
Deposited By: George Porter
Deposited On:09 Apr 2019 21:09
Last Modified:16 Nov 2021 17:06

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