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Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo

Bedzhov, Ivan and Graham, Sarah J. L. and Leung, Chuen Yan and Zernicka-Goetz, Magdalena (2014) Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 369 (1657). Art. No. 20130538. ISSN 0962-8436. PMCID PMC4216461; PMC4275920. http://resolver.caltech.edu/CaltechAUTHORS:20190409-154015645

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Abstract

A critical point in mammalian development is when the early embryo implants into its mother's uterus. This event has historically been difficult to study due to the fact that it occurs within the maternal tissue and therefore is hidden from view. In this review, we discuss how the mouse embryo is prepared for implantation and the molecular mechanisms involved in directing and coordinating this crucial event. Prior to implantation, the cells of the embryo are specified as precursors of future embryonic and extra-embryonic lineages. These preimplantation cell fate decisions rely on a combination of factors including cell polarity, position and cell–cell signalling and are influenced by the heterogeneity between early embryo cells. At the point of implantation, signalling events between the embryo and mother, and between the embryonic and extraembryonic compartments of the embryo itself, orchestrate a total reorganization of the embryo, coupled with a burst of cell proliferation. New developments in embryo culture and imaging techniques have recently revealed the growth and morphogenesis of the embryo at the time of implantation, leading to a new model for the blastocyst to egg cylinder transition. In this model, pluripotent cells that will give rise to the fetus self-organize into a polarized three-dimensional rosette-like structure that initiates egg cylinder formation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1098/rstb.2013.0538DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216461/PubMed CentralArticle
https://doi.org/10.1098/rstb.2014.0339DOICorrection
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275920/PubMed CentralCorrection
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. Theme Issue ‘From pluripotency to differentiation: laying the foundations for the body pattern in the mouse embryo’ compiled and edited by Magdalena Zernicka-Goetz and Anna-Katerina Hadjantonakis We wish to thank the Wellcome Trust and University of Cambridge for our funding.
Errata:The authors would like to add the following acknowledgment to their manuscript: Acknowledgements: We would like to thank Anna Hakes for her contribution to the design of figure 3 in the article.
Funders:
Funding AgencyGrant Number
Wellcome TrustUNSPECIFIED
University of CambridgeUNSPECIFIED
Subject Keywords:embryo, morphogenesis, cell fate, differentiation, pluripotency
PubMed Central ID:PMC4216461; PMC4275920
Record Number:CaltechAUTHORS:20190409-154015645
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190409-154015645
Official Citation:Bedzhov I, Graham SJL, Leung CY, Zernicka-Goetz M. 2014 Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo. Phil. Trans. R. Soc. B 369: 20130538. http://dx.doi.org/10.1098/rstb.2013.0538
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94608
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:09 Apr 2019 22:51
Last Modified:09 Apr 2019 22:51

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