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From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo

Zernicka-Goetz, Magdalena and Hadjantonakis, Anna-Katerina (2014) From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 369 (1657). Art. No. 20130535. ISSN 0962-8436. PMCID PMC4216458. https://resolver.caltech.edu/CaltechAUTHORS:20190409-162629840

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Abstract

A central question in contemporary stem and developmental biology and modern medicine is how developmental potential becomes progressively restricted as development proceeds. How totipotency—namely the ability to give rise to both embryonic and extraembryonic tissues and, in an ideal situation to the entire organism—is lost. How do cells choose between alternative fates, and how do they stereotypically organize themselves into developing tissues? Today, one can strip differentiated cells of their identity by inducing pluripotency, but it is still largely unknown how pluripotency emerges in its native context within the early embryo. Indeed, the only true pluripotent cell population—the epiblast—exists in vivo within the early mammalian embryo.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1098/rstb.2013.0535DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216458/PubMed CentralArticle
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2014 The Author(s) Published by the Royal Society. One contribution of 14 to a Theme Issue ‘From pluripotency to differentiation: laying the foundations for the body pattern in the mouse embryo’.
Subject Keywords:mouse embryo, pluripotency, differentiation
Issue or Number:1657
PubMed Central ID:PMC4216458
Record Number:CaltechAUTHORS:20190409-162629840
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190409-162629840
Official Citation:Zernicka-Goetz Magdalena and Hadjantonakis Anna-Katerina From pluripotency to differentiation: laying foundations for the body pattern in the mouse embryo369Philosophical Transactions of the Royal Society B: Biological Sciences http://doi.org/10.1098/rstb.2013.0535
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94610
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:10 Apr 2019 14:57
Last Modified:03 Oct 2019 21:05

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