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A tribute to Sir John Gurdon

Rosenthal, Nadia and Zernicka-Goetz, Magdalena (2014) A tribute to Sir John Gurdon. Differentiation, 88 (1). pp. 1-2. ISSN 0301-4681. doi:10.1016/j.diff.2014.11.001. https://resolver.caltech.edu/CaltechAUTHORS:20190409-163953574

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Abstract

Since he was awarded the Nobel Prize in 2012, John Gurdon׳s remarkable contributions to biology have been celebrated in innumerable reviews and commentaries. He has since claimed that his early observations, that nuclei from differentiated cells could be reprogrammed by the factors in a fertilized egg to rerun the entire embryonic program, should not surprise us – after all, the sperm nucleus is reprogrammed by the oocyte with every fertilization event. Indeed John׳s original reports in the 1970s, documenting a pluripotent stem cell state in nuclei from fully differentiated frog intestinal epithelial cells induced by the egg cytoplasm, were to wait almost forty years before receiving the accolades they deserved.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.diff.2014.11.001DOIArticle
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2014 International Society of Differentiation. Published by Elsevier. Available online 20 November 2014.
Issue or Number:1
DOI:10.1016/j.diff.2014.11.001
Record Number:CaltechAUTHORS:20190409-163953574
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190409-163953574
Official Citation:Nadia Rosenthal, Magdalena Zernicka-Goetz, A tribute to Sir John Gurdon, Differentiation, Volume 88, Issue 1, 2014, Pages 1-2, ISSN 0301-4681, https://doi.org/10.1016/j.diff.2014.11.001. (http://www.sciencedirect.com/science/article/pii/S0301468114000723)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94611
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:10 Apr 2019 15:32
Last Modified:16 Nov 2021 17:06

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