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MicroRNA-125 in Immunity and Cancer

Wang, Jessica K. and Wang, Zhe and Li, Guideng (2019) MicroRNA-125 in Immunity and Cancer. Cancer Letters, 454 . pp. 134-145. ISSN 0304-3835.

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MicroRNAs (miRNAs) are small non-coding RNAs that play a wide variety of critical roles in different biological processes by post-transcriptionally regulating gene expression. They access diverse regulatory pathways during various stages of cellular differentiation, growth, and apoptosis, and can contribute to both normal and diseased functions. One important family of miRNAs involved in these functions is the miR-125 family (miR-125a and miR-125b). Investigations have been made to increasingly uncover the mechanisms by which the miR-125 family regulates normal homeostasis and growth in a variety of cell types including immune cells, and how dysregulation of miR-125a and miR-125b can lead to disease pathogenesis and tumorigenesis. In this review, we summarize what is currently known about miR-125a and miR-125b, mainly focusing on their roles in immune cell development and function as well as tumor suppression and promotion.

Item Type:Article
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URLURL TypeDescription
Wang, Jessica K.0000-0003-1421-4969
Li, Guideng0000-0003-0840-7262
Additional Information:© 2019 Published by Elsevier B.V. Received 19 February 2019, Revised 9 April 2019, Accepted 9 April 2019, Available online 12 April 2019.
Record Number:CaltechAUTHORS:20190415-142956358
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Official Citation:Jessica K. Wang, Zhe Wang, Guideng Li, MicroRNA-125 in immunity and cancer, Cancer Letters, Volume 454, 2019, Pages 134-145, ISSN 0304-3835, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94714
Deposited By: Tony Diaz
Deposited On:16 Apr 2019 21:32
Last Modified:17 Apr 2019 15:56

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