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Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate

Bruce, Alexander W. and Zernicka-Goetz, Magdalena (2010) Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate. Current Opinion in Genetics and Development, 20 (5). pp. 485-491. ISSN 0959-437X. http://resolver.caltech.edu/CaltechAUTHORS:20190417-163114658

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Abstract

The temporal and spatial segregation of the two extra-embryonic cell lineages, trophectoderm and primitive endoderm (TE and PE respectively), from the pluripotent epiblast (EPI) during mammalian pre-implantation development are prerequisites for the successful implantation of the blastocyst. The mechanisms underlying these earliest stages of development remain a fertile topic for research and informed debate. In recent years novel roles for various transcription factors, polarity factors and signalling cascades have been uncovered. This mini-review seeks to summarise some of this work and to put it into the context of the regulative nature of early mammalian development and to highlight how the increasing evidence of naturally occurring asymmetries and heterogeneity in the embryo can bias specification of the distinct cell types of the blastocyst.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.gde.2010.05.006DOIArticle
ORCID:
AuthorORCID
Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2010 Elsevier. Available online 14 June 2010. We are grateful to the Wellcome Trust and the Ministry of Education (6007665801), Czech Republic for supporting our work.
Funders:
Funding AgencyGrant Number
Wellcome TrustUNSPECIFIED
Ministry of Education (Czech Republic)6007665801
Record Number:CaltechAUTHORS:20190417-163114658
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20190417-163114658
Official Citation:Alexander W Bruce, Magdalena Zernicka-Goetz, Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate, Current Opinion in Genetics & Development, Volume 20, Issue 5, 2010, Pages 485-491, ISSN 0959-437X, https://doi.org/10.1016/j.gde.2010.05.006. (http://www.sciencedirect.com/science/article/pii/S0959437X1000095X)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94770
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Apr 2019 22:26
Last Modified:18 Apr 2019 22:26

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