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The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice

Zernicka-Goetz, Magdalena (2006) The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice. Current Opinion in Genetics and Development, 16 (4). pp. 406-412. ISSN 0959-437X. doi:10.1016/j.gde.2006.06.011.

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Development of the early mouse embryo has always been classified as regulative, meaning that when parts or blastomeres of the embryo are isolated they change their developmental fate and can even reconstruct the whole. However, regulative development does not mean that, in situ, these parts or blastomeres are equivalent; it does not mean that the early mammalian embryo is a ball of identical cells without any bias. Regulative development simply means that whatever bias the regions of the embryo might have they still remain flexible and can respond to experimental interference by changes of fate. This realization — that regulative development and patterning can co-exist — has led to a renaissance of interest in the first days of development of the mouse embryo, and several laboratories have provided evidence for some early bias. Now the challenge is to gain some understanding of the molecular basis of this bias.

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Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 2006 Elsevier. Available online 23 June 2006. Our research on development of pattern and cell fate in the early mouse embryo is supported by grants from the Wellcome Trust and the Biotechnology and Biological Sciences Research Council. The title of this essay is a modification of the quotation, ‘Destiny is no matter of chance, it is a matter of choice: it is not a thing to be waited for, it is a thing to be achieved’ by William Jennings Bryan.
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Biotechnology and Biological Sciences Research Council (BBSRC)UNSPECIFIED
Issue or Number:4
Record Number:CaltechAUTHORS:20190419-105736662
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Official Citation:Magdalena Zernicka-Goetz, The first cell-fate decisions in the mouse embryo: destiny is a matter of both chance and choice, Current Opinion in Genetics & Development, Volume 16, Issue 4, 2006, Pages 406-412, ISSN 0959-437X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94809
Deposited By: George Porter
Deposited On:23 Apr 2019 16:14
Last Modified:16 Nov 2021 17:08

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