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RNA Interference in Mammalian Systems - A Practical Approach

Grabarek, Joanna B. and Zernicka-Goetz, Magdalena (2003) RNA Interference in Mammalian Systems - A Practical Approach. In: Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology . No.544. Springer , Boston, MA, pp. 205-216. ISBN 9781461347828.

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RNAi-related mechanisms are evolutionarily conserved and are a tool for cells to defend against foreign nucleic acid invasion and thus genomic instability in the cell. Double-stranded RNA is relatively easy to produce in vitro and, its introduction generates knockout phenotypes without the need to interfere at the DNA level. Thus, the discovery of RNAi has greatly contributed to research by providing a new genetic tool. This chapter presents the comparative view on the RNAi-releated techniques and discusses their practical applications in different mammalian experimental systems, including their therapeutic potential.

Item Type:Book Section
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Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© Springer Science+Business Media New York 2003. The authors would like to thank Dr S. Frankenberg (Wellcome CR UK Institute, Cambridge) for useful discussion during writing this chapter.
Series Name:Advances in Experimental Medicine and Biology
Issue or Number:544
Record Number:CaltechAUTHORS:20190422-100408600
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94836
Deposited By: George Porter
Deposited On:23 Apr 2019 16:00
Last Modified:16 Nov 2021 17:08

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