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Activation of embryonic genes during preimplantation rat development

Zernicka-Goetz, Magdalena (1994) Activation of embryonic genes during preimplantation rat development. Molecular Reproduction and Development, 38 (1). pp. 30-35. ISSN 1040-452X. doi:10.1002/mrd.1080380106.

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Expression of the embryonic genome has been examined during preimplantation rat development. Proteins synthesized at different stages of embryogenesis were labelled with [^(35)S]methionine and then separated by one‐dimensional gel electrophoresis. A major transformation in the pattern of protein synthesis has been observed between the two‐ and the four‐cell stages of embryonic development. Also the culture of embryos with an inhibitor of transcription (α‐amanitin) has shown that the first α‐amanitin‐sensitive events take place during the late two‐cell stage. However, inhibition of transcription does not arrest the embryo development up to the four‐cell stage. Taken together, the results indicate that in rats the initiation of embryonic gene activation occurs at the late two‐cell stage. However, the first two cleavage divisions can occur in the absence of transcription.

Item Type:Article
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Zernicka-Goetz, Magdalena0000-0002-7004-2471
Additional Information:© 1994 Wiley‐Liss. Manuscript received: 21 January 1993. Manuscript accepted: 07 June 1993.
Subject Keywords:Rat embryo; Transcription; Protein synthesis
Issue or Number:1
Record Number:CaltechAUTHORS:20190422-101736535
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Official Citation:Zernicka‐Goetz, M. (1994), Activation of embryonic genes during preimplantation rat development. Mol. Reprod. Dev., 38: 30-35. doi:10.1002/mrd.1080380106
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94858
Deposited By: George Porter
Deposited On:23 Apr 2019 18:15
Last Modified:16 Nov 2021 17:08

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