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Filling in the phylogenetic gaps: induction, migration and differentiation of neural crest cells in a squamate reptile, the Veiled Chameleon (Chamaeleo calyptratus)

Diaz, Raul E., Jr. and Shylo, Natalia A. and Roellig, Daniela and Bronner, Marianne and Trainor, Paul A. (2019) Filling in the phylogenetic gaps: induction, migration and differentiation of neural crest cells in a squamate reptile, the Veiled Chameleon (Chamaeleo calyptratus). Developmental Dynamics, 248 (8). pp. 709-727. ISSN 1058-8388. https://resolver.caltech.edu/CaltechAUTHORS:20190423-133133773

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Abstract

Neural crest cells comprise a migratory progenitor cell population that differentiate into cell types such as neurons and glia of the peripheral nervous system, pigment cells, hormone secreting cells in glands, and skeletal and connective tissue in the head, thus making important contributions to most tissues and organs throughout the vertebrate body. The evolutionary appearance of neural crest cells is considered synonymous with the origin of vertebrates and their subsequent diversification and radiation. While the comparative biology of neural crest cells has been studied for a century and a half beginning with their discovery by Wilhelm His in 1868 (His, 1868), most of our understanding of their development and function has come from a small number of species. Thus, critical gaps exist in our understanding of how neural crest cells mediate evolution and development. This is particularly true with respect to squamate reptiles (lizards, snakes, amphisbaenians), which account for about one‐third of all living tetrapods. Here we present veiled chameleons (Chamaeleo calyptratus) as a model system for studying neural crest cell development in squamates. Chameleons exhibit various morphological specializations associated with an arboreal lifestyle that may have been facilitated through neural crest cells acting as a conduit for evolutionary change.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1002/dvdy.38DOIArticle
ORCID:
AuthorORCID
Roellig, Daniela0000-0002-7558-3592
Bronner, Marianne0000-0003-4274-1862
Trainor, Paul A.0000-0003-2774-3624
Additional Information:© 2019 Wiley Periodicals, Inc. Accepted manuscript online: 13 April 2019; Manuscript accepted: 04 April 2019; Manuscript revised: 04 April 2019; Manuscript received: 16 January 2019.
Subject Keywords:Neural crest cells; Squamate; Reptile; Chameleon; Evolution; Induction; Migration; HNK1; Neurulation; Cranial Nerves; Skeletogenesis
Issue or Number:8
Record Number:CaltechAUTHORS:20190423-133133773
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190423-133133773
Official Citation:Diaz, RE, Shylo, NA, Roellig, D, Bronner, M, Trainor, PA. Filling in the phylogenetic gaps: Induction, migration, and differentiation of neural crest cells in a squamate reptile, the veiled chameleon (Chamaeleo calyptratus). Developmental Dynamics. 2019; 248: 709–727. https://doi.org/10.1002/dvdy.38
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:94895
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:23 Apr 2019 20:51
Last Modified:03 Oct 2019 21:08

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