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Parylene neuro-cages for live neural networks study

He, Qing and Meng, Ellis and Tai, Yu-Chong and Rutherglen, Christopher M. and Erickson, Jon and Pine, Jerome (2003) Parylene neuro-cages for live neural networks study. In: TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers. Vol.2. IEEE , Piscataway, NJ, pp. 995-998. ISBN 0780377311.

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Here we present a surface-micromachined Parylene neuro-cage array for the in vitro study of live neural networks. Various types of neuro-cages have been fabricated and several adhesion promotion techniques have been explored. The biocompatibility and mechanical robustness of Parylene neuro-cages have been demonstrated through cell culture experiments. Dissociated neuronal cell bodies have been inserted one to a cage and cultured, allowing neurites to grow out through Parylene channels and form live neural networks. In addition, there is no observable difference between neural growth on Parylene and on oxide surfaces. It is possible to use the same or slightly modified cage structures to accommodate different cells, leading to possible applications of this technology in cell study and drug discovery.

Item Type:Book Section
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Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2003 IEEE. This work is supported by the NSF ERC program at Caltech (Award No. EEC-9402726) and NIH (Award No. R01 NSO44134).
Funding AgencyGrant Number
Center for Neuromorphic Systems Engineering, CaltechUNSPECIFIED
NIHR01 NSO44134
Record Number:CaltechAUTHORS:20190501-154133989
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Official Citation:Qing He, E. Meng, Yu-Chong Tai, C. M. Rutherglen, J. Erickson and J. Pine, "Parylene neuro-cages for live neural networks study," TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664), Boston, MA, USA, 2003, pp. 995-998 vol.2. doi: 10.1109/SENSOR.2003.1216935
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95150
Deposited By: George Porter
Deposited On:02 May 2019 14:31
Last Modified:16 Nov 2021 17:10

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