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A miniaturized neuroprosthesis suitable for implantation into the brain

Mojarradi, Mohammad and Binkley, David and Blalock, Benjamin and Andersen, Richard and Ulshoefer, Norbert and Johnson, Travis and Del Castillo, Linda (2003) A miniaturized neuroprosthesis suitable for implantation into the brain. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 11 (1). pp. 38-42. ISSN 1534-4320. doi:10.1109/tnsre.2003.810431.

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This paper presents current research on a miniaturized neuroprosthesis suitable for implantation into the brain. The prosthesis is a heterogeneous integration of a 100-element microelectromechanical system (MEMS) electrode array, front-end complementary metal-oxide-semiconductor (CMOS) integrated circuit for neural signal preamplification, filtering, multiplexing and analog-to-digital conversion, and a second CMOS integrated circuit for wireless transmission of neural data and conditioning of wireless power. The prosthesis is intended for applications where neural signals are processed and decoded to permit the control of artificial or paralyzed limbs. This research, if successful, will allow implantation of the electronics into the brain, or subcutaneously on the skull, and eliminate all external signal and power wiring. The neuroprosthetic system design has strict size and power constraints with each of the front-end preamplifier channels fitting within the 400 x 400 µm pitch of the 100-element MEMS electrode array and power dissipation resulting in less than a 1° C temperature rise for the surrounding brain tissue. We describe the measured performance of initial micropower low-noise CMOS preamplifiers for the neuroprosthetic.

Item Type:Article
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Andersen, Richard0000-0002-7947-0472
Additional Information:© 2003 IEEE. Manuscript received July 10, 2002; revised March 25, 2003. This work was supported under a contract with the Defense Advanced Research Projects Agency for the California Institute of Technology. The authors acknowledge the assistance of D. H. Ihme and C. E. Hopper of the University of North Carolina at Charlotte for their assistance in preamplifier measurements and preparing this paper.
Funding AgencyGrant Number
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Subject Keywords:Bio-MEMS, brain, complementary metal–oxide–semiconductor (CMOS) micropower, computer interface, cortical signals, heterogeneous integration, integrated-circuit electronics, low-noise preamplifiers, microelectromechanical system (MEMS) packaging, microelectromechanical system (MEMS) probe, neuroprosthesis, neuroprosthetic devices
Issue or Number:1
Record Number:CaltechAUTHORS:20190501-154134344
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Official Citation:M. Mojarradi et al., "A miniaturized neuroprosthesis suitable for implantation into the brain," in IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 11, no. 1, pp. 38-42, March 2003. doi: 10.1109/TNSRE.2003.810431
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95154
Deposited By: George Porter
Deposited On:01 May 2019 23:08
Last Modified:16 Nov 2021 17:10

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