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The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase

Masters, Jeffrey N. and Attardi, Giuseppe (1983) The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase. Gene, 21 (1-2). pp. 59-63. ISSN 0378-1119. https://resolver.caltech.edu/CaltechAUTHORS:20190501-163158420

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Abstract

The nucleotide sequence of the human dihydrofolic acid reductase (DHFR) reading frame has been derived from the analysis of human DHFR cDNA. This sequence and the corresponding amino acid sequence have been compared with those available for the enzyme and its coding segment from other organisms. There is an 89% nucleotide sequence homology between the human DHFR reading frame and the mouse coding sequence. Furthermore, amino acid-sequence homologies of 74%, 81% and 89% has been found between human DHFR and chicken, bovine and mouse DHFR, respectively.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/0378-1119(83)90147-6DOIArticle
Additional Information:© 1983 Published by Elsevier. Received 13 October 1982, Accepted 15 October 1982. This investigation was supported by NIH grants GM-11726 and T32 GM-07616.
Funders:
Funding AgencyGrant Number
NIHGM11726
NIH Predoctoral FellowshipT32 GM07616
Subject Keywords:Recombinant DNA; Maxam-Gilbert sequencing; comparison with mouse, bovine and chicken DHFR; sequence conservation
Issue or Number:1-2
Record Number:CaltechAUTHORS:20190501-163158420
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20190501-163158420
Official Citation:Jeffrey N. Masters, Giuseppe Attardi, The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase, Gene, Volume 21, Issues 1–2, 1983, Pages 59-63, ISSN 0378-1119, https://doi.org/10.1016/0378-1119(83)90147-6. (http://www.sciencedirect.com/science/article/pii/0378111983901476)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:95158
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:02 May 2019 15:35
Last Modified:03 Oct 2019 21:10

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