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Detecting directional coupling in the human epileptic brain: Limitations and potential pitfalls

Osterhage, Hannes and Mormann, Florian and Wagner, Tobias and Lehnertz, Klaus (2008) Detecting directional coupling in the human epileptic brain: Limitations and potential pitfalls. Physical Review E, 77 (1). Art. No. 011914. ISSN 1539-3755. doi:10.1103/PhysRevE.77.011914.

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We study directional relationships—in the driver-responder sense—in networks of coupled nonlinear oscillators using a phase modeling approach. Specifically, we focus on the identification of drivers in clusters with varying levels of synchrony, mimicking dynamical interactions between the seizure generating region (epileptic focus) and other brain structures. We demonstrate numerically that such an identification is not always possible in a reliable manner. Using the same analysis techniques as in model systems, we study multichannel electroencephalographic recordings from two patients suffering from focal epilepsy. Our findings demonstrate that—depending on the degree of intracluster synchrony—certain subsystems can spuriously appear to be driving others, which should be taken into account when analyzing field data with unknown underlying dynamics.

Item Type:Article
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Mormann, Florian0000-0003-1305-8028
Additional Information:©2008 The American Physical Society. (Received 4 April 2007; revised 4 June 2007; published 22 January 2008) The authors are grateful to Stephan Bialonski, Dieter Krug, and Matthäus Staniek for useful discussions and most valuable comments. This work was supported by the Deutsche Forschungsgemeinschaft (Contract No. SFB TR3 Subproject A2), by BONFOR, the intramural research fund of the University of Bonn and by the 6th Framework Programme of the European Commission (Marie Curie OIF).
Group:Koch Laboratory (KLAB)
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)SFB TR3 Subproject A2
Marie Curie Fellowship040445
Subject Keywords:diseases; electroencephalography; nonlinear dynamical systems; time series
Issue or Number:1
Classification Code: PACS: 87.19.L−, 05.45.Xt, 05.45.Tp, 05.10.−a
Record Number:CaltechAUTHORS:OSTpre08
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:9518
Deposited By: Archive Administrator
Deposited On:29 Jan 2008
Last Modified:08 Nov 2021 20:59

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